PMID: 11309162Apr 20, 2001Paper

Connectivity patterns in tuberculosis and leprosy patients are indistinguishable from that of healthy donors

Scandinavian Journal of Immunology
T Tovar-RiveraF J Sánchez-García

Abstract

Connectivity, the self-defined interactions between antigen-recognising molecules in a network system can in part be assessed by measuring the reactivity of a given serum against an ordered set of immunoglobulin (Ig)G F(ab')2 fractions, separated by means of isoelectric focusing so that, the serum reactivity against the whole set of fractions defines a characteristic pattern of connectivity. Deviations from the normal condition (healthy donors) have so far been documented for two autoimmune diseases: systemic lupus erythematosus (SLE) and pemphigus vulgaris, as well as for human immunodeficiency virus (HIV)-1 infection. We tested here if bacterial infections lead to alterations in connectivity. In addition, we wanted to test if two antigenically related bacteria would produce similar or otherwise distinctive connectivity patterns. Connectivity analysis was applied on the sera from tuberculosis and leprosy patients and the sera from healthy donors were used as control. No statistically significant differences between the three groups studied were found. These results have implications for theories that set the origin of autoimmune diseases in microbial infections. To the best of our knowledge, this is the first attempt to analyz...Continue Reading

References

May 1, 1978·Medical Hypotheses·N M Vaz, F J Varela
Nov 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M CostelloC Moreno
Aug 21, 1992·Science·B R Bloom, C J Murray
Feb 1, 1991·Infection and Immunity·D V HavlirJ J Ellner
Apr 7, 1991·Journal of Theoretical Biology·R J de Boer, A S Perelson
Aug 1, 1989·Immunological Reviews·J Stewart, F J Varela
Aug 1, 1989·Immunological Reviews·A Coutinho
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D YoungR A Young
Jan 1, 1987·Arthritis and Rheumatism·O SelaY Shoenfeld
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W van EdenI R Cohen
Jan 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T F Brewer, G A Colditz
Dec 1, 1994·Scandinavian Journal of Immunology·A DrowartJ P van Vooren
Sep 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·W J Britton
Mar 1, 1996·European Journal of Immunology·A AyoubaA Coutinho
Apr 29, 1999·Scandinavian Journal of Immunology·U Pacheco-GarcíaF J Sánchez-García
Apr 5, 2000·The Journal of Experimental Medicine·M R EhrensteinM S Neuberger
Dec 19, 2000·Scandinavian Journal of Immunology·L Padierna-OlivosF J Sánchez-García

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Citations

Sep 7, 2007·Annals of the New York Academy of Sciences·Natalia Pavón-MartínezVictor Manuel Monteón
Jul 21, 2004·The Veterinary Record·S Martínez-SubielaJ J Cerón

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