Connectome-Based Model Predicts Deep Brain Stimulation Outcome in Parkinson's Disease

Frontiers in Computational Neuroscience
Ruihong ShangXuesong Li

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective invasive treatment for advanced Parkinson's disease (PD) at present. Due to the invasiveness and cost of operations, a reliable tool is required to predict the outcome of therapy in the clinical decision-making process. This work aims to investigate whether the topological network of functional connectivity states can predict the outcome of DBS without medication. Fifty patients were recruited to extract the features of the brain related to the improvement rate of PD after STN-DBS and to train the machine learning model that can predict the therapy's effect. The functional connectivity analyses suggested that the GBRT model performed best with Pearson's correlations of r = 0.65, p = 2.58E-07 in medication-off condition. The connections between middle frontal gyrus (MFG) and inferior temporal gyrus (ITG) contribute most in the GBRT model.

References

Jul 1, 1983·Archives of General Psychiatry·M F FolsteinJ E Helzer
Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·G L DeferM Levivier
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·François TisonGregor K Wenning
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia RamakerBob Johannes Van Hilten
Oct 10, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Christian BrenneisGregor K Wenning
Dec 10, 2003·Current Opinion in Neurobiology·Alim Louis Benabid
Dec 14, 2004·The New England Journal of Medicine·Stanley FahnUNKNOWN Parkinson Study Group
Jul 18, 2006·Brain : a Journal of Neurology·Kotaro AsanumaDavid Eidelberg
Sep 1, 2006·The New England Journal of Medicine·Günther DeuschlUNKNOWN German Parkinson Study Group, Neurostimulation Section
Sep 15, 2006·Psychopharmacology·Erin B McClureDaniel S Pine
May 29, 2007·Trends in Neurosciences·Constance HammondPeter Brown
Sep 13, 2007·The Neurologist·Ramon L RodriguezMichael S Okun
Jan 19, 2008·AJNR. American Journal of Neuroradiology·A T Karagulle KendiP Tuite
Nov 5, 2008·Neurosurgery·Tina-Marie EllisMichael S Okun
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Apr 4, 2009·AJNR. American Journal of Neuroradiology·G GattellaroM G Bruzzone
Jul 15, 2009·Archives of Neurology·Thilo van EimerenAntonio P Strafella
Mar 23, 2010·Brain : a Journal of Neurology·Marjan JahanshahiAndrew J Lees
Jun 4, 2010·Expert Review of Neurotherapeutics·Thomas Foltynie, Marwan I Hariz
Mar 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Sook K SongPhil Hyu Lee
Feb 7, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wen-bin GuoJing-ping Zhao
Jun 9, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Angelo AntoniniFrancesca Del Sorbo
Dec 1, 2012·Brain : a Journal of Neurology·Carl D HackerAbraham Z Snyder
Jul 13, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Katherine L PossinJoel H Kramer
Nov 26, 2013·Brain : a Journal of Neurology·Kim T E Olde DubbelinkHenk W Berendse
Sep 14, 2014·Neurology·Rubens G CuryDaniel Ciampi de Andrade
Dec 17, 2014·Behavioural Brain Research·Jiuquan ZhangTianzi Jiang
Feb 5, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Roberta BiundoAngelo Antonini
May 2, 2015·Journal of Neurology·Chun Yan LuoHui-Fang Shang
Sep 9, 2015·Frontiers in Human Neuroscience·Jinhui WangYong He
May 28, 2016·Cerebral Cortex·Lingzhong FanTianzi Jiang
Mar 24, 2017·Nature Reviews. Disease Primers·Werner PoeweAnthony E Lang
Jun 7, 2017·Annals of Neurology·Andreas HornMichael D Fox
Oct 21, 2017·Brain : a Journal of Neurology·Jinhee KimAntonio P Strafella
Oct 27, 2017·Brain Connectivity·Raíssa Benocci ThibesJoão Ricardo Sato
Feb 20, 2019·Biological Psychiatry·Juan Carlos BaldermannJens Kuhn

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Software Mentioned

SPM
GRETNA
GBRT
Lead
Brainnetome Atlas ( BNA
- DBS
BNA

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