PMID: 11904615Mar 21, 2002Paper

Connexin 43 expression in normal versus dysfunctional labor

American Journal of Obstetrics and Gynecology
Brian T PierceLisa M Pierce

Abstract

We sought to determine whether connexin 43 (Cx43), the major myometrial gap junction protein, is differentially expressed in normal versus dysfunctional labor. Myometrial biopsies were obtained from 28 patients undergoing cesarean section and grouped into the following categories: (1) no labor, (2) dysfunctional labor, and (3) normal labor. Northern and Western analyses were performed to determine Cx43 messenger RNA (mRNA) and protein expression, respectively. Localization of Cx43 protein was determined by immunohistochemistry. Labor was associated with increased Cx43 mRNA expression (P <.05). This association was not true for protein. There was no difference in mRNA or protein expression between patients with normal labor versus those with dysfunctional labor. The extent of Cx43 immunohistochemical staining was not significantly different among the groups (P >.05). Dysfunctional labor is not associated with aberrant Cx43 mRNA or protein expression or with a reduction in immunodetectable Cx43 gap junctions.

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Citations

Apr 9, 2013·Tissue Engineering. Part a·Roger C Young, Gabriela Goloman
May 6, 2006·Reproductive Biology and Endocrinology : RB&E·Ann Hjelm CluffGunvor Ekman-Ordeberg
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Mark TattersallMark R Johnson
Nov 23, 2013·American Journal of Obstetrics and Gynecology·Chandrasekhar ThotaNahed Ismail
Jan 2, 2021·The Journal of Pharmacology and Experimental Therapeutics·Scott D BarnettIain L O Buxton

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