PMID: 9437659Jan 23, 1998Paper

Connexin 43 mRNA expression in two experimental models of epilepsy

Molecular and Chemical Neuropathology
K ElisevichN Allar

Abstract

The expression of mRNA for connexin 43, a gap junction protein putatively found in astrocytes, is studied in two experimental models of epilepsy: the electrically kindled rat and the tetanus-toxin-injected rat. Rats were kindled by electrical stimulation of the amygdala to Racine class 5 seizures and divided into cohorts of three to undergo 3, 6, or 10 such events, respectively. Another two cohorts of rats received injections of tetanus toxin at strengths of 3 and 9 MLD50, respectively, into the amygdala. Features of epileptogenicity were identified electrographically in both cohorts during the first 4 wk following toxin injection with spontaneous ictal events recorded in the latter cohort. All rats were sacrificed 4 wk after electrode or cannula implantation, except for two toxin-injected cohorts that were sacrificed at wk 8 or 10. The epileptogeonic area in the region of the amygdala was harvested and pooled by cohort for Northern blot analysis. These were compared with control nonimplanted tissues. In the tetanus-toxin-injected animals, at time-points of 4, 8, and 10 wk, connexin 43 mRNA expression in epileptogenic tissues is found to be decreased or unchanged relative to control cases. Kindled rats demonstrated reductions o...Continue Reading

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Citations

Nov 24, 2011·Neuroscience Bulletin·Miao-Miao Jin, Zhong Chen
Jan 30, 2013·Neurochemistry International·Peter Bedner, Christian Steinhäuser
Aug 2, 2002·European Journal of Pharmacology·Christian Steinhäuser, Gerald Seifert
Feb 16, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Siamak BeheshtiBehrouz Vaziri
Jan 17, 2015·Neuroscience·C SteinhäuserG Carmignoto
May 27, 1999·Molecular and Chemical Neuropathology·K ElisevichK Hirst
Mar 13, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Vincenzo CrunelliChristian Steinhäuser
Nov 26, 2020·Biomolecules·Laura WalraveIlse Smolders

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