Connexin Hemichannels in Astrocytes: Role in CNS Disorders

Frontiers in Molecular Neuroscience
LingYan XingGang Chen

Abstract

In the central nervous system (CNS), astrocytes form networks interconnected by gap junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an adjoining hemichannel, astrocytic connexins can act as hemichannels to control the release of small molecules such as ATP and glutamate into the extracellular space. Accruing evidence indicates that astrocytic connexins are crucial for the coordination and maintenance of physiologic CNS activity. Here we provide an update on the role of astrocytic connexins in neurodegenerative disorders, glioma, and ischemia. In addition, we address the regulation of Cx43 in chronic pain.

References

Mar 15, 2001·Neuroscience Research·P Song, Z Q Zhao
Apr 3, 2003·Nature Reviews. Molecular Cell Biology·Daniel A Goodenough, David L Paul
Sep 25, 2003·Physiological Reviews·Juan C SaezEric C Beyer
Oct 31, 2003·Trends in Neurosciences·Michael V L BennettJuan C Sáez
Oct 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Leah E SpataroLinda R Watkins
Jun 16, 2005·Biochimica Et Biophysica Acta·Joell L Solan, Paul D Lampe
Oct 8, 2005·Science·Olivier PascualPhilip G Haydon
Dec 14, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mauricio A RetamalChristian Giaume
Dec 6, 2008·Cell Death and Differentiation·J J RodríguezA Verkhratsky
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong-Jing GaoRu-Rong Ji
Sep 11, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akiko Okada-OgawaKoichi Iwata
Sep 22, 2009·European Journal of Pharmacology·Joanna MikaBarbara Przewlocka
Dec 17, 2009·Pain·Amanda R WeyerbacherCharles E Inturrisi
Jun 2, 2010·Pflügers Archiv : European journal of physiology·Ghayda HawatGhayath Baroudi
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexei VerkhratskyJose Julio Rodriguez
Oct 16, 2010·Nature Medicine·Ke Ren, Ronald Dubner
Dec 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Juan M GarréVerónica Abudara
Mar 5, 2011·Lancet·Clive BallardEmma Jones
Mar 5, 2011·Brain : a Journal of Neurology·Makoto TsudaKazuhide Inoue
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan A OrellanaChristian Giaume
May 31, 2011·Cell Calcium·Elke DecrockLuc Leybaert
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·David JohansenSvein-Ole Mikalsen
Sep 22, 2011·Biochimica Et Biophysica Acta·Claire A ScottDavid P Kelsell
Oct 20, 2011·Biochimica Et Biophysica Acta·Annette KoulakoffChristian Giaume
Nov 9, 2011·Biochimica Et Biophysica Acta·Wun-Chey SinMarc Mesnil
Jan 6, 2012·Cleveland Clinic Journal of Medicine·Hubert H Fernandez
Jan 26, 2012·Annals of Neurology·Joanne O DavidsonAlistair Jan Gunn
Feb 22, 2012·Brain : a Journal of Neurology·Helen V Danesh-MeyerColin R Green
May 29, 2012·Neurochemical Research·C-Y ChiangJ O Dostrovsky
Jul 4, 2012·International Journal of Molecular Sciences·Joanne O DavidsonAlistair J Gunn
Nov 21, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shinji TsuchidaToshikazu Kubo
Nov 23, 2012·Current Drug Targets·Joanne O DavidsonAlistair J Gunn
Feb 20, 2013·Cellular and Molecular Life Sciences : CMLS·Chunzhang YangZhengping Zhuang
Jun 21, 2013·Molecular Medicine Reports·Yu WangQunying Fu
Jun 25, 2013·Pain·Ru-Rong JiMaiken Nedergaard

❮ Previous
Next ❯

Citations

Dec 19, 2019·Stem Cells and Development·Masoumeh Zarei-KheirabadiHossein Baharvand
Sep 12, 2020·SLAS Discovery·Emmanuelle SoleilhacMathieu Charvériat
Sep 20, 2020·Pharmaceutics·Norwin KubickMichel-Edwar Mickael
May 28, 2019·Frontiers in Cellular Neuroscience·Renáta VinczeZsolt Kovács
Dec 24, 2019·Bioscience Reports·Jin-Ting HeXin Zhao
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jieying WangXiangyang Guo
Dec 1, 2019·International Journal of Molecular Sciences·Laura Medina-CejaAlberto Morales-Villagrán
Jul 19, 2020·International Journal of Molecular Sciences·Gürsel ÇalışkanAnne Albrecht
May 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Dong Young KimYoung-Guen Kwon
Jul 17, 2020·Frontiers in Cellular and Infection Microbiology·Anna Maria Gorska, Eliseo A Eugenin
Jun 9, 2020·Journal of Molecular Neuroscience : MN·Saereh HosseindoostMahmoudreza Hadjighassem
Jul 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Melissa L CooperDavid J Calkins
Oct 28, 2019·Journal of Neuroinflammation·Guo-Chuang DengGang Chen
Feb 6, 2020·Frontiers in Pharmacology·Raúl Lagos-CabréLisette Leyton
Jan 6, 2021·Future Medicinal Chemistry·Yagya P SubediCheng-Wei T Chang
Aug 28, 2020·Reviews in the Neurosciences·Dorothea DereEkrem Dere
Jan 9, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Damiano BurattoFabio Mammano
Dec 22, 2020·Seizure : the Journal of the British Epilepsy Association·Ting-Ting YangFeng-Ru Tang
Dec 29, 2020·Journal of Advanced Research·Abdullah Al MamunJian Xiao
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Carmen Ruiz-CanteroEnrique J Cobos
Dec 16, 2020·Immunobiology·Abdullah Al MamunJian Xiao
Feb 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·M CharvériatA Verkhratsky
Oct 30, 2020·International Journal of Molecular Sciences·Elena V MitroshinaMaria V Vedunova
Dec 19, 2020·International Journal of Molecular Sciences·Tomoya Kitayama
Nov 17, 2020·Frontiers in Cellular Neuroscience·Jeiwon Cho, Yeowool Huh
Aug 8, 2020·Life Sciences·Qian LiYu-Xia Chu
Mar 7, 2021·International Journal of Molecular Sciences·Paloma A HarchaBrigitte van Zundert
Mar 13, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Cristina M NathaGuillermo A Altenberg
Apr 4, 2021·International Journal of Molecular Sciences·Hongyun XuanHuihua Yuan
Apr 25, 2021·Progress in Neurobiology·Matthew J Broadhead, Gareth B Miles
Aug 8, 2021·International Journal of Molecular Sciences·Carmen NanclaresPaulo Kofuji
Sep 19, 2021·The Journal of Allergy and Clinical Immunology·Melissa A RosenkranzWilliam W Busse
Nov 20, 2021·Neurochemical Research·Jun-Yi LongXiao-Peng Ma

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
transfection
GTPase

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Acta Physiologica Scandinavica
Juan C SáezMichael V L Bennett
Proceedings of the National Academy of Sciences of the United States of America
Ulrike PannaschNathalie Rouach
© 2022 Meta ULC. All rights reserved