PMID: 9183689Jun 2, 1997Paper

Connexin43 and astrocytic gap junctions in the rat spinal cord after acute compression injury

The Journal of Comparative Neurology
E TheriaultJ I Nagy

Abstract

To examine the possible role of interastrocytic gap junctions in the maintenance of tissue homeostasis after spinal cord damage, we initiated studies of the astrocytic gap junctional protein connexin43 (Cx43) in relation to temporal and spatial parameters of neuronal loss, reactive gliosis, and white matter survival in a rat model of traumatic spinal cord injury (SCI). Cx43 immunolocalization in normal and compression-injured spinal cord was compared by using two different sequence-specific anti-Cx43 antibodies that have previously exhibited different immunorecognition properties at lesion sites in brain. At 1- and 3-day survival times, gray matter areas with mild to moderate neuronal depletion exhibited a loss of immunolabeling with one of the two antibodies. At the lesion epicenter, these areas consisted of a zone that separated normal staining distal to the lesion from intensified labeling seen with both antibodies immediately adjacent to the lesion. Loss of immunoreactivity with only one of the two antibodies suggested masking of the corresponding Cx43 epitope. By 7 days post-SCI, Cx43 labeling was absent with both antibodies in all regions extending up to 1 mm from the lesion site. Reactive astrocytes displaying glial fibr...Continue Reading

Citations

Oct 31, 2012·PloS One·Nicolas TheodoricWun-Chey Sin
Oct 12, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nathan M KerrHelen V Danesh-Meyer
Oct 6, 2011·Journal of Neuroscience Research·Ann WuGila Moalem-Taylor

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