Connexins and pannexins: Coordinating cellular communication in the testis and epididymis.

Spermatogenesis
D G Cyr

Abstract

Gap junctions and connexins are critical for coordinating cellular functions in complex epithelia. In recent years there has been increased interest in understanding the regulation and function of gap junctions in both the testis and epididymis. Studies in transgenic mice in which connexin 43 (Cx43) is mutated or is knocked down only in Sertoli cells have demonstrated the essential role of Cx43 in spermatogenesis and differentiation of Sertoli cells. In the epididymis developmental studies have shown a role for numerous connexins in the differentiation of epithelial cells and communication between the basal cells and both principal and clear cells. In both tissues several factors, such thyroid hormones and androgens, are important in regulating expression and function of connexins. Pannexins, which form cellular channels but are structurally similar to gap junction proteins, have been identified in both testis and epididymis and, in the epididymis, are regulated by androgens. The objective of this review is to summarize the advances that have been made on the role and regulation of connexins and pannexins in the testis and epididymis and their implication in spermatogenesis and sperm maturation.

References

Jan 1, 1979·The American Journal of Anatomy·E L Sun, C J Flickinger
Oct 1, 1992·The Journal of Cell Biology·R A MeyerR G Johnson
Jun 1, 1972·The Journal of Cell Biology·D S Friend, N B Gilula
Apr 1, 1972·The Journal of Cell Biology·D S Friend, N B Gilula
Aug 1, 1994·The American Journal of Physiology·E M Pérez-ArmendarizA P Moreno
Feb 1, 1995·Biology of Reproduction·B Robaire, R S Viger
Jan 1, 1995·Microscopy Research and Technique·D G CyrL Hermo
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L BrissetteG P Dotto
Aug 1, 1994·The American Journal of Physiology·W A Varanda, A C de Carvalho
Feb 9, 1996·Cell·N M Kumar, N B Gilula
Jan 1, 1996·Annual Review of Biochemistry·D A GoodenoughD L Paul
May 28, 1998·The Journal of Biological Chemistry·T ToyofukuM Tada
Dec 29, 1998·The Journal of Biological Chemistry·S A JohnJ N Weiss
Apr 20, 1999·Biology of Reproduction·S C JunejaG M Kidder
Sep 25, 1999·Journal of Cellular Physiology·S S ChungC Y Cheng
Dec 3, 1999·Biochemical and Biophysical Research Communications·T KojimaD C Spray
Sep 21, 2000·Current Biology : CB·A PlumK Willecke
Nov 15, 2000·Biological Chemistry·A Stock, H Sies
Aug 22, 2001·Biology of Reproduction·W A RoscoeG M Kidder
Jul 11, 2002·Biological Chemistry·Klaus WilleckeGoran Söhl
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Julie DufresneDaniel G Cyr
Mar 22, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Norah DefamieGeorges Pointis
Sep 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jorge E ContrerasMichael V L Bennett
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Roberto BruzzoneHannah Monyer
Dec 19, 2003·Cell Communication & Adhesion·Goran Söhl, Klaus Willecke
Dec 19, 2003·Cell Communication & Adhesion·Jorge E ContrerasMichael V L Bennett
Apr 28, 2004·Molecular and Cellular Endocrinology·Christiane KirchhoffMarie-Claire Orgebin-Crist
Dec 2, 2004·Brain Research. Brain Research Reviews·Jorge E ContrerasJuan C Sáez
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Steven Goossens, Frans van Roy

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Citations

Jan 5, 2013·Human Reproduction Update·Xiang XiaoC Yan Cheng
May 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jiali CaiZhenghong Zuo
Oct 22, 2013·Reproduction, Fertility, and Development·S Arrighi
Feb 13, 2016·Nature Communications·Jeremy RoySylvie Breton
May 29, 2014·Systems Biology in Reproductive Medicine·Chunhong CaiDawei He
Jan 19, 2016·Seminars in Cell & Developmental Biology·Gerald M Kidder, Daniel G Cyr
Jun 27, 2014·PLoS Genetics·Xiang XiaoC Yan Cheng
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miao LongJun Wang
Sep 25, 2015·Biology of Reproduction·Marion MandonDaniel G Cyr
Nov 8, 2014·Biology of Reproduction·Julie Dufresne, Daniel G Cyr
Jul 31, 2018·Biology of Reproduction·Mary Gregory, Daniel G Cyr
Apr 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura GirardetClémence Belleannée
Sep 14, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Nedenia Bonvino StafuzzaFernando Baldi
Apr 30, 2019·Andrology·R SullivanD Soulet
Nov 26, 2021·Frontiers in Cell and Developmental Biology·Francesco ManfrevolaFlorian Guillou

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