Connexins: gaps in our knowledge of vascular function

Physiology
Xavier F FigueroaB R Duling

Abstract

Gap junctions are common features in the vasculature, long thought to provide a pathway for cell-cell signaling. Emerging understanding of the gap-junctional proteins (connexins) and new tools for their investigation now offer the opportunity to explore the vital role that the gap junctions may play in cardiovascular homeostasis and pathophysiology.

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