Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

Pharmacological Reviews
Luc LeybaertRainer Schulz

Abstract

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane hemichannels and as intercellular gap junction channels that directly connect cells. In the heart, gap junction channels electrically connect myocytes and specialized conductive tissues to coordinate the atrial and ventricular contraction/relaxation cycles and pump function. In blood vessels, these channels facilitate long-distance endothelial cell communication, synchronize smooth muscle cell contraction, and support endothelial-smooth muscle cell communication. In the central nervous system they form cellular syncytia and coordinate neural function. Gap junction channels are normally open and hemichannels are normally closed, but pathologic conditions may restrict gap junction communication and promote hemichannel opening, thereby disturbing a delicate cellular communication balance. Until recently, most connexin-targeting agents exhibited little specificity and several off-target effects. Recent work with peptide-based approaches has demonstrated improved specificity and opened avenues for a more rational approach toward independently modulating the function of gap junctions and hemichannels. We here review the role of connexins and their chan...Continue Reading

References

Aug 1, 1979·Journal of Oral Pathology·H O Archard, F R Denys
Nov 1, 1992·Pflügers Archiv : European journal of physiology·B R Takens-Kwak, H J Jongsma
Aug 1, 1992·The American Journal of Physiology·K D MasseyJ M Burt
Oct 1, 1990·Pflügers Archiv : European journal of physiology·G S FluriR Weingart
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G I FishmanL A Leinwand
Mar 1, 1991·The American Journal of Physiology·J M BurtB N Minnich
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J F Hare, K Taylor
Jul 1, 1990·The Journal of Membrane Biology·E C BeyerD A Goodenough
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Oct 1, 1987·The American Journal of Physiology·J M Burt
May 1, 1989·Pflügers Archiv : European journal of physiology·M B RookB de Jonge
Jul 1, 1989·Circulation Research·N J SeversC R Green
Jun 1, 1989·Molecular and Cellular Endocrinology·J A AhlquistM C Sheppard
Dec 1, 1987·The Journal of Cell Biology·E C BeyerD A Goodenough
Jan 1, 1989·British Journal of Pharmacology·H InoueY Koshihara
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C SaezM V Bennett
Jan 15, 1987·Biochemical and Biophysical Research Communications·C K ManjunathJ P Revel
Aug 1, 1987·Pflügers Archiv : European journal of physiology·P Maurer, R Weingart
Apr 1, 1986·Journal of Molecular and Cellular Cardiology·M J JanseF Wilms-Schopman
Dec 1, 1986·Biophysical Journal·R W Joyner, F J van Capelle
May 1, 1970·The Journal of Cell Biology·D A Goodenough, J P Revel

❮ Previous
Next ❯

Citations

Mar 16, 2018·International Journal of Molecular Sciences·Robert D Johnson, Patrizia Camelliti
Dec 1, 2017·International Journal of Molecular Sciences·Odunayo O MugishoIlva D Rupenthal
Dec 9, 2017·Cellular and Molecular Life Sciences : CMLS·Jegan IyyathuraiGeert Bultynck
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Kerstin BoenglerRainer Schulz
Oct 13, 2018·Nature Reviews. Drug Discovery·Dale W Laird, Paul D Lampe
Jul 18, 2019·Assay and Drug Development Technologies·Christèle PicoliMathieu Charvériat
Jul 25, 2019·Frontiers in Physiology·Yu ZhangHalina Dobrzynski
Apr 28, 2018·International Journal of Molecular Sciences·Trond AasenMichael Koval
Oct 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mohd Nasir Mat NorMonica L Acosta
Sep 15, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Martin MaibierAxel R Pries
Dec 17, 2019·Cardiovascular Research·Alessio LissoniLuc Leybaert
Jan 31, 2020·Circulation Research·David A EisnerDavid C Hutchings
Jan 30, 2020·British Journal of Pharmacology·Kerstin BoenglerRainer Schulz
May 19, 2020·Clinical and Experimental Hypertension : CHE·Noushin YazdaniSaeid Taheri
Jun 4, 2020·Journal of Cellular and Molecular Medicine·Derek J HausenloyFabio Di Lisa
Sep 11, 2019·Cellular and Molecular Life Sciences : CMLS·Max Zachrisson TotlandEdward Leithe
Sep 12, 2020·SLAS Discovery·Emmanuelle SoleilhacMathieu Charvériat
Mar 16, 2019·The Journal of Experimental Medicine·Moises Freitas-AndradeChristian C Naus
Apr 20, 2018·International Journal of Molecular Sciences·Michel DoschGuido Beldi
Jun 8, 2018·International Journal of Molecular Sciences·Filippo MolicaJonathan M Gibbins
Feb 28, 2019·Frontiers in Physiology·Jean-François DenisBrenda R Kwak
Apr 23, 2020·Drug Delivery and Translational Research·Frazer P CoutinhoIlva D Rupenthal
Dec 20, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Robert G Gourdie
Dec 12, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Odunayo O MugishoIlva D Rupenthal
Sep 6, 2018·Cold Spring Harbor Perspectives in Medicine·Fabio Mammano
May 16, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Babken Asatryan, Argelia Medeiros-Domingo
Apr 25, 2020·Physiological Reviews·Christian GiaumeLuc Leybaert
Apr 11, 2018·American Journal of Physiology. Cell Physiology·Maura L CotterJanis M Burt
Mar 29, 2018·Current Medicinal Chemistry·Denis SarrouilheCatherine Dejean
Sep 20, 2018·Scientific Reports·S MoscatoL Mattii

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