Connexins in neurons and glia: targets for intervention in disease and injury

Neural Regeneration Research
Keith B Moore, John O'Brien

Abstract

Both neurons and glia throughout the central nervous system are organized into networks by gap junctions. Among glia, gap junctions facilitate metabolic homeostasis and intercellular communication. Among neurons, gap junctions form electrical synapses that function primarily for communication. However, in neurodegenerative states due to disease or injury gap junctions may be detrimental to survival. Electrical synapses may facilitate hyperactivity and bystander killing among neurons, while gap junction hemichannels in glia may facilitate inflammatory signaling and scar formation. Advances in understanding mechanisms of plasticity of electrical synapses and development of molecular therapeutics to target glial gap junctions and hemichannels offer new hope to pharmacologically limit neuronal degeneration and enhance recovery.

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Citations

Aug 1, 2016·Biochimica Et Biophysica Acta·Luana HeimfarthRegina Pessoa-Pureur
Sep 7, 2016·International Journal of Molecular Sciences·Patrizia ProiaItalia Di Liegro
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Mar 29, 2018·Current Medicinal Chemistry·Denis SarrouilheCatherine Dejean
Feb 6, 2020·Frontiers in Pharmacology·Raúl Lagos-CabréLisette Leyton
Apr 18, 2018·Frontiers in Molecular Neuroscience·Valeria C LabraJuan A Orellana

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