Connexins in the sinoatrial and atrioventricular nodes

Advances in Cardiology
Mark R BoyettHalina Dobrzynski

Abstract

The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle). These functions have special requirements regarding electrical coupling and, therefore, expression of connexin isoforms. Electrical coupling in the center of the SAN should be weak to protect it from the inhibitory electrotonic influence of the more hyperpolarized non-pacemaking atrial muscle surrounding the SAN. However, for the SAN to be able to drive the atrial muscle, electrical coupling should be strong in the periphery of the SAN. Consistent with this, in the center of the SAN there is no expression of Cx43 (the principal connexin of the working myocardium) and little expression of Cx40, but there is expression of Cx45 and Cx30.2, whereas in the periphery of the SAN Cx43 as well Cx45 is expressed. In the AVN, there is a similar pattern of expression of connexins as in the center of the SAN and this is likely to be in large part responsible for the slow conduction of the action potential.

Citations

Jul 23, 2011·Basic Research in Cardiology·Chin-Feng TsaiYi-Jen Chen
Oct 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Solena Le ScouarnecPeter J Mohler
Jan 5, 2011·PLoS Computational Biology·Ronit V Oren, Colleen E Clancy
Jan 28, 2015·Molecular Medicine Reports·Ling SunZhiwei Zhang
Aug 17, 2012·Journal of Biomedical Optics·Christina M AmbrosiIgor R Efimov
Mar 17, 2011·Channels·Laurine MargerMatteo E Mangoni
Nov 19, 2014·Frontiers in Physiology·Stefan DheinFriedrich-Wilhelm Mohr
Jul 11, 2014·Frontiers in Physiology·Ashley M NisbetGodfrey L Smith
May 12, 2016·Circulation·Roy M John, Saurabh Kumar
Apr 11, 2007·Circulation·Halina DobrzynskiRobert H Anderson
Dec 28, 2018·Anatomia, histologia, embryologia·Mahmoud Abdelghaffar Emam, Ahmed I Abo-Ahmed
Dec 19, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·William J HuckerIgor R Efimov
Apr 14, 2010·Journal of Cardiovascular Electrophysiology·Jean-Benoit Le Polain DE WarouxLaurent Macle
Oct 16, 2010·Pacing and Clinical Electrophysiology : PACE·Oliver MonfrediGwilym M Morris
Dec 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Abhijit GurjarpadhyeRobert G Gourdie
Jul 16, 2008·Physiological Reviews·Matteo E Mangoni, Joël Nargeot
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Stefano RossiEmilio Macchi
Feb 15, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Aida Salameh, Stefan Dhein
Jul 24, 2013·Molecular and Cellular Biochemistry·Sherin I Hashem, William C Claycomb
Sep 22, 2017·Pharmacological Reviews·Luc LeybaertRainer Schulz
Jul 25, 2019·Frontiers in Physiology·Yu ZhangHalina Dobrzynski
Sep 15, 2019·Experimental & Molecular Medicine·Jin-Mo GuHee Cheol Cho
Sep 14, 2019·Cell Cycle·Jessica PichéGregor Andelfinger
Aug 15, 2009·Cardiovascular Research·Daniel GrosMatteo E Mangoni
Nov 25, 2016·Experimental and Therapeutic Medicine·Yaqiong XiaoHalina Dobrzynski
May 5, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Cliona Murphy, Ralph Lazzara
Jul 14, 2018·Bulletin of Experimental Biology and Medicine·G A Abalakov, P V Sutyagin
Oct 28, 2019·Pflügers Archiv : European journal of physiology·Alexandra D IvanovaVlad S Kuzmin
Jul 1, 2020·Pflügers Archiv : European journal of physiology·Angelo G TorrenteMatteo E Mangoni
Apr 24, 2012·Cardiovascular Research·Steven N Ebert
Oct 26, 2018·Circulation Research·Jorge A Castorena-GonzalezMichael J Davis
Jun 22, 2016·Cardiovascular Research·Matteo E Mangoni

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