Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues

International Review of Cell and Molecular Biology
Daniel González-NietoJ A Cancelas

Abstract

Life-long hematopoietic demands are met by a pool of hematopoietic stem cells (HSC) with self-renewal and multipotential differentiation ability. Humoral and paracrine signals from the bone marrow (BM) hematopoietic microenvironment control HSC activity. Cell-to-cell communication through connexin (Cx) containing gap junctions (GJs) allows pluricellular coordination and synchronization through transfer of small molecules with messenger activity. Hematopoietic and surrounding nonhematopoietic cells communicate each other through GJs, which regulate fetal and postnatal HSC content and function in hematopoietic tissues. Traffic of HSC between peripheral blood and BM is also dependent on Cx proteins. Cx mutations are associated with human disease and hematopoietic dysfunction and Cx signaling may represent a target for therapeutic intervention. In this review, we illustrate and highlight the importance of Cxs in the regulation of hematopoietic homeostasis under normal and pathological conditions.

Citations

Jan 30, 2020·International Journal of Molecular Sciences·Abhishek K Singh, Jose A Cancelas
Feb 23, 2020·Stroke; a Journal of Cerebral Circulation·Akie Kikuchi-TauraAkihiko Taguchi
Mar 31, 2018·Current Stem Cell Reports·Nafiisha GenetKaren K Hirschi

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