Conopressin affects excitability, firing, and action potential shape through stimulation of transient and persistent inward currents in mulluscan neurons

Journal of Neurophysiology
P F van Soest, K S Kits

Abstract

The molluscan vasopressin/oxytocin-related neuropeptide conopressin activates two persistent inward currents in neurons from the anterior lobe of the right cerebral ganglion of Lymnaea stagnalis that are involved in the control of male copulatory behavior. The low-voltage-activated (LVA) current is activated at a wide range of membrane potentials, its amplitude being only weakly voltage dependent. The high-voltage-activated (HVA) current is activated at potentials positive to -40 mV only and shows a steep voltage dependence. Occurrence of both currents varies from cell to cell, some expressing both and others only the HVA current. In most neurons that have the LVA current, a conopressin-independent persistent inward current (INSR) is found that resembles the HVA current in its voltage dependence. The functional importance of the LVA and HVA currents was studied under current-clamp conditions in isolated anterior lobe neurons. In cells exhibiting both current types, the effect of activation of the LVA current alone was investigated as follows: previously recorded LVA current profiles were injected into the neurons, and the effects were compared with responses induced by conopressin. Both treatments resulted in a strong depolariz...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B Hochner, E R Kandel
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B A Goldsmith, T W Abrams
Feb 1, 1992·Canadian Journal of Physiology and Pharmacology·M Martínez-PadrónK Lukowiak
May 1, 1985·The Journal of Physiology·R H Kramer, R S Zucker
Jan 1, 1985·Progress in Biophysics and Molecular Biology·W B Adams, J A Benson
Feb 16, 1996·The Journal of Biological Chemistry·R E van KesterenW P Geraerts
Dec 1, 1996·Trends in Neurosciences·J MagistrettiE Wanke
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B HochnerE R Kandel

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Citations

Aug 21, 2013·Experimental Physiology·Christian W Gruber
Apr 6, 2018·Marine Drugs·Ashlin H TurnerChristina I Schroeder
Nov 30, 2016·Neurotoxicology·Jafar VatanparastMaryam Naseh
Jun 8, 2021·RSC Medicinal Chemistry·Ashlin TurnerDavid J Craik

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