PMID: 22352912Feb 23, 2012Paper

Conotoxins: review and docking studies to determine potentials of conotoxin as an anticancer drug molecule

Current Topics in Medicinal Chemistry
Kirtan Dave, Anasuya Lahiry

Abstract

It is known that potassium channels are important for cell proliferation. HERG, a potassium channel protein, is a transmembrane protein, which increases in concentration on the cell surface of cancer cells. Apart from cancer cells, this protein is found only in the brain & heart tissue, in very low number. The proliferation of cells in cancer is dependent on activation of this protein, and it has been noted that blocking of this protein with drug molecule, helps inhibit the proliferation of the cells further. The current work aims to study the binding potentials of κ-PVIIA, conotoxin isolated from Conus purpurascens venom with HERG K+ channel of tumor cells, where HERG mutation has been noted. The toxin under consideration i.e. κ-conotoxins-PVIIA (κ-PVIIA) is a 27 residue peptide. The docking studies suggest that the conotoxin binds stably to the HERG protein. The study shows that the peptide interacts with the charged extracellular unit of the HERG protein, i.e. the extracellular portion of the S5 domain named S5-P extracellular linker. Study of binding of toxins of similar origin, with normal potassium channels has been studied in silico. Further, wet laboratory work needs to be conducted for development of a drug molecule fr...Continue Reading

Citations

Jul 24, 2012·Marine Drugs·Magbubah EssackJohn A C Archer
Aug 26, 2014·Experimental Eye Research·Nadine Reichhart, Olaf Strauss
Jul 3, 2016·Integrative and Comparative Biology·J Gorson, M Holford
Aug 11, 2020·Natural Product Reports·Xin LuanWei-Dong Zhang
Apr 5, 2020·Marine Drugs·Rocio K Finol-UrdanetaAhmed Al-Sabi
Jul 28, 2020·Biomedicines·Walden E Bjørn-YoshimotoHelena Safavi-Hemami
Oct 20, 2019·Marine Drugs·Prachi AnandMandë Holford
Oct 8, 2020·Journal of Cosmetic Dermatology·Pengfei SunBo Pan
Apr 4, 2021·Pharmaceuticals·Christina Vijayaraghavan SathynathanMary Elizabeth Gnanambal Krishnan
Jul 9, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Manyi YangMaojun Zhou
Dec 11, 2013·Journal of Chemical Information and Modeling·Aliuska Duardo-SánchezHumberto González-Díaz

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