PMID: 9182771Jun 27, 1997Paper

Consanguinity and common adult diseases in Israeli Arab communities

American Journal of Medical Genetics
L JaberM Shohat

Abstract

Consanguinity has a deleterious effect with regard to congenital malformation and rare autosomal recessive diseases; however, little information exists on its role in multifactorial common adult morbidity. We investigated the effects of consanguinity on the prevalence of common diseases in adulthood, including diabetes mellitus, myocardial infarction, bronchial asthma, and duodenal ulcer. As part of a larger study investigating the inbreeding coefficient in the Israeli-Arab community, we distributed questionnaires to parents of 4,100 second-grade students in 158 randomly chosen schools. Among the 3,772 responders (92%), 34.8% of the students' fathers and 31% of their mothers were found to be born to consanguineous matings. There was no difference in the prevalence (males, females) between the offspring of consanguineous versus non-consanguineous matings for diabetes mellitus (consanguinity: 4.3%, 1.5% vs. non-consanguinity: 2.9%, 1.6%) myocardial infarction (2.7%, 0.03% vs. 2.3%, 0.03%), bronchial asthma (2.4%, 2.0% vs. 3.7%, 2.3%), or duodenal ulcer (7.0%, 3.0% vs. 7.8%, 2.9%), respectively. The study suggests that even in a population with a high rate of consanguinity, there is no significant increase in the prevalence of the...Continue Reading

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Citations

Aug 2, 2012·International Journal of Endocrinology·Mohammad Badran, Ismail Laher
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·A H Bittles, M L Black
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Jun 2, 2007·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Abdulbari BenerAhmad S Teebi
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Apr 16, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ariela Gordon-ShaagEinat Shneor
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Dec 9, 2021·Nutrition and Cancer·Issa Ghrouz, Nuha El Sharif

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