Consanguinity and eye diseases with a potential genetic etiology. Data from a prevalence study in Andhra Pradesh, India

Ophthalmic Epidemiology
Praveen K NirmalanRavi Thomas

Abstract

To determine the prevalence of consanguinity and its potential associations with eye diseases in Andhra Pradesh state of south India. As part of a demographic interview schedule, prior to clinical examinations, trained investigators collected information regarding consanguinity of the parents from subjects randomly chosen for a population-based cross-sectional epidemiological study. Each subject underwent a detailed ocular examination including visual acuity measurements, anterior segment examinations with slit-lamp biomicroscopy, and posterior segment examinations. Adjusted odds ratios (OR), attributable risks (AR) and population attributable risks (PAR) were estimated. We obtained details regarding consanguinity of the parents from 10,290 of the 10,293 subjects who were enumerated and examined in the study. Parental consanguinity was reported by 1822 (24.7%) rural subjects and 782 (32.9%) urban subjects. Eighty (0.008%, 95% CI: 0.006, 0.010) of the 9757 subjects had an ocular disease with a potential genetic basis. We found microcornea to be significantly associated with both an uncle-niece relationship (adjusted OR: 7.32, 95% CI: 1.73, 30.97, AR = 86.34%, PAR = 42.11%) and a first-cousin relationship between the parents (adj...Continue Reading

References

Jun 1, 1990·Journal of Medical Genetics·M L Kulkarni, M Kurian
May 1, 1985·Annals of Human Biology·K L Hann
Apr 25, 2000·Indian Journal of Pediatrics·B V Bhat, L Babu
Apr 4, 2001·Journal of Biosocial Science·S Krishnamoorthy, N Audinarayana
Nov 13, 2002·Archives of Ophthalmology·John Paul SanGiovanniMark A Klebanoff
Feb 25, 2003·The British Journal of Ophthalmology·S J HornbyC E Gilbert
Mar 28, 2003·Ophthalmic Epidemiology·Jonathan M HolmesDavid O Hodge
Jan 30, 2004·Clinical & Experimental Ophthalmology·Jane R MacKinnonDavid A Mackey
Feb 13, 2004·Community Genetics·G KumaramanickavelN Shridhara Shetty

❮ Previous
Next ❯

Citations

Mar 22, 2013·Indian Journal of Ophthalmology·Sundaram Natarajan
Nov 14, 2008·Ophthalmic Genetics·Justin C SherwinDavid A Mackey
May 19, 2012·Acta Ophthalmologica·Vinay NangiaAjit Sinha
Jun 23, 2009·Transcultural Psychiatry·Saleh M Al-SalehiMohammad Ghaziuddin
Dec 6, 2020·Journal français d'ophtalmologie·B M DiatewaK Patrice Balo
Mar 18, 2021·Clinical Ophthalmology·Rosa M Coco-MartinHortensia Sanchez-Tocino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.