Conscious sedation in the critically ill ventilated patient

Journal of Critical Care
Marco CigadaGaetano Iapichino

Abstract

The aim of sedation is to provide comfort and minimize anxiety. However, adverse effects are noteworthy, and the optimal end point of sedation in intensive care unit patients is still debated. We analyzed if a level 2 on the Ramsay Scale (ie, awake, cooperative, oriented, tranquil patient) is suitable for an invasive therapeutic approach. Forty-two patients requiring respiratory support and sedation for at least 4 days were enrolled in a prospective interventional cohort study aiming at maintaining patients awake and collaborative. The Ramsay score was recorded 3 times a day. Once a day, the nurse in charge evaluated adequacy of sedation according to the compliance with nursing care and therapeutic maneuvers in the previous 24 hours. Data were collected until patients were ventilated. Overall, 264 of 582 days were classified as conscious. Sedation was adequate in 93.9% of them. In conscious days, a higher Simplified Acute Physiology Score II score and male sex significantly correlated with inadequate sedation. In a population of severe intensive care unit patients, conscious sedation was achieved in almost half of the days spent on ventilation. The positive implications (eg, on length of weaning and cost of sedation) of a conse...Continue Reading

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References

Jan 1, 1992·Statistical Methods in Medical Research·J M Neuhaus
Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
May 1, 2001·Current Opinion in Critical Care·Gavin G. Lavery, Paul Glover
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·John P KressJesse B Hall
Oct 4, 2003·American Journal of Respiratory and Critical Care Medicine·John P KressJesse B Hall
Feb 18, 2004·Intensive Care Medicine·Jeffery C WoodsAlejandro C Arroliga
May 7, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Giorgio ContiRodolfo Proietti
Jan 13, 2005·Critical Care Medicine·Bernard De JongheHervé Outin
Feb 17, 2005·Intensive Care Medicine·Marco CigadaGaetano Iapichino
Aug 10, 2005·Seminars in Respiratory and Critical Care Medicine·C N SesslerG M Brophy
Nov 12, 2005·Intensive Care Medicine·Ingrid EgerodLena Johansen

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Citations

Nov 24, 2011·Pain Research and Treatment·F CevikC Macit
Apr 5, 2013·Trials·Giovanni MistralettiUNKNOWN SedaEN investigators
Oct 5, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Benedikt Trabold, Thomas Metterlein
Jun 19, 2013·Medicina intensiva·E Celis-RodríguezUNKNOWN Federación Panamericana e Ibérica de Sociedades de Medicina Crítica y Terapia Intensiva
Oct 9, 2012·Best Practice & Research. Clinical Anaesthesiology·Giovanni MistralettiCesare Gregoretti
Jul 14, 2009·Journal of Critical Care·Giovanni MistralettiGaetano Iapichino
Jan 9, 2019·Critical Care : the Official Journal of the Critical Care Forum·Giovanni MistralettiUNKNOWN SedaEN investigators
Apr 25, 2009·Current Opinion in Anaesthesiology·Giovanni M Pittoni, Alessio Scatto

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