Consecutive Cyproterone Acetate and Estradiol Treatment in Late-Pubertal Transgender Female Adolescents

The Journal of Sexual Medicine
Lloyd J W TackMartine Cools

Abstract

Cyproterone acetate (CA) is an antiandrogenic progestin commonly used in adult transwomen to suppress endogenous androgens, often in combination with estrogens to induce feminization. To assess the (side) effects and biochemical changes of CA alone and in combination with estrogens in adolescent trans-girls. This study was a retrospective analysis of clinical and biochemical data from 27 trans-girls who presented at Tanner stage G4 and were treated with CA monotherapy for at least 6 months (mean = 12 months) and then in combination with incremental doses of estrogens (CA + E; mean = 16 months). Statistical analysis of data included paired or unpaired Student t-test or Wilcoxon signed-ranks or Mann-Whitney U-test as appropriate. Anthropometrics, reported beneficial and side effects, safety parameters, and hormone levels. Physical changes included decrease of facial and non-facial hair growth. One third showed breast development under CA (Tanner stages B2-B3), which increased to Tanner stages B3 and B4 in 66.7% and 9.5% respectively, during CA + E. Reported side effects during CA and CA + E were breast tenderness, emotionality, fatigue, and flushes. No relevant weight changes were observed. Main safety parameters showed the follo...Continue Reading

Citations

Apr 20, 2018·The Journal of Clinical Endocrinology and Metabolism·Lloyd J W TackMartine Cools
Oct 12, 2018·Endocrine Reviews·Guy T'SjoenVin Tangpricha
Jul 28, 2018·European Journal of Endocrinology·Laetitia MartinerieSabine E Hannema
Nov 10, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Julia Cartaya, Ximena Lopez
Aug 17, 2018·Reviews in Endocrine & Metabolic Disorders·Leonidas Panagiotakopoulos
Jul 9, 2021·Dermatology and Therapy·Catherine C Motosko, Antonella Tosti
Sep 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Michele A O'ConnellKen C Pang

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