Consecutive Measurements by Faecal Immunochemical Test in Quiescent Ulcerative Colitis Patients Can Detect Clinical Relapse

Journal of Crohn's & Colitis
Sakiko HiraokaHiroyuki Okada

Abstract

We have reported that results of the quantitative faecal immunochemical test (FIT; haemoglobin concentrations in faeces measured using an antibody for human haemoglobin) effectively reflect the mucosal status of ulcerative colitis (UC). The aim of this study was to evaluate the predictability of flare-up in quiescent UC patients by consecutive FIT evaluation. Patients with UC who fulfilled the following criteria by index colonoscopy were enrolled: clinical remission; mucosal healing (Mayo endoscopic subscore 0); and negative FIT (less than 100ng/mL). These patients were followed up prospectively every 1-3 months by monitoring patient symptoms and FIT results between index and subsequent colonoscopies. The intervals between 2 colonoscopies (median 2.51 years) of 83 patients (49 males, median age at onset 34 years, median disease duration 9.74 years) were analysed. None of the 43 (52%) patients who maintained negative FIT throughout the observation period exhibited clinical relapse. On the other hand, 25/40 (63%) patients who showed positive conversion of FIT during the period experienced relapse. The cutoff FIT value of 450ng/mL could predict relapse with 73% positive predictive value and 96% negative predictive value. Moreover,...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Mar 18, 2009·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Feb 10, 2010·Gastroenterology·Francis A FarrayeUNKNOWN AGA Institute Medical Position Panel on Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease
Mar 6, 2010·World Journal of Gastroenterology : WJG·Motoaki KuriyamaKazuhide Yamamoto
Apr 30, 2010·Gut·Stuart R CairnsUNKNOWN Association of Coloproctology for Great Britain and Ireland
Sep 24, 2011·Journal of Crohn's & Colitis·Laurent Peyrin-BirouletUNKNOWN Scientific Committee of the European Crohn's and Colitis Organization
Nov 15, 2011·European Journal of Internal Medicine·Natalia López-PalaciosManuel Díaz-Rubio
May 23, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sameer D SainiPeter D R Higgins
Sep 26, 2012·The American Journal of Gastroenterology·Asuka NakaraiKazuhide Yamamoto
Nov 5, 2013·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN European Crohn's and Colitis Organisation
Dec 18, 2013·International Journal of Colorectal Disease·Takayuki YamamotoKoichi Matsumoto
May 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark T OstermanUNKNOWN DEAR Investigators
May 31, 2014·Inflammatory Bowel Diseases·Aranzazu Jauregui-AmezagaMaría Pellise
Apr 1, 2015·The American Journal of Gastroenterology·Shiho TakashimaKazuhide Yamamoto

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Citations

Aug 17, 2018·Immunopharmacology and Immunotoxicology·Yiqing WangLihua Yang
Mar 16, 2019·Expert Review of Clinical Immunology·Jun KatoSakiko Hiraoka
Mar 26, 2019·The American Journal of Gastroenterology·Ryan UngaroLaurent Peyrin-Biroulet
Jan 10, 2018·Scandinavian Journal of Gastroenterology·Pasquale KleppStephan Brackmann
Jan 28, 2020·Scandinavian Journal of Gastroenterology·Eun Soo KimUNKNOWN Crohn’s and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Jan 30, 2021·Clinical and Translational Gastroenterology·Natsuki IshidaKen Sugimoto
Apr 23, 2021·Journal of Gastroenterology·Hiroshi NakaseKazuhiko Koike
Jun 26, 2021·World Journal of Gastroenterology : WJG·Natsuki IshidaKen Sugimoto

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