Abstract
Platelet transfusion is about to commemorate its 50th year since its introduction in therapeutics. It is then surprising to see, that in spite of reaching this respectful age, we have not been able to definitely establish all the aspects related to its clinical use. Some of these facets are platelet transfusion threshold and the platelet dose to administer. Historically, two different transfusion triggers have been used for prophylactic and therapeutic platelet transfusions. For prophylactic platelet transfusion an increasing body of evidences suggests that a transfusion trigger of 10 x 10(9) per liter is appropriate for most clinical settings. In contrast, evidence for supporting a certain therapeutic transfusion trigger is lacking. Nevertheless, there is consensus that the platelet count should not be allowed to fall below 50 x 10(9) per liter in patients with acute bleeding. Another important aspect still pending of clear definition is the issue of the platelet dose to be transfused. It has been addressed by some small studies but a definite answer to this important clinical issue is, at least so far, still pending. The results of two ongoing trials, one sponsored by NIH through the Clinical Trials Network in Transfusion Med...Continue Reading
References
Nov 16, 1991·Lancet·J GmürA Schaffner
Apr 3, 1987·JAMA : the Journal of the American Medical Association
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K D HeckmanC P Burns
Dec 20, 1997·The New England Journal of Medicine·P RebullaG Sirchia
Jul 21, 1999·Transfusion·T R KlumppK F Mangan
Nov 25, 2000·British Journal of Haematology·E J Freireich
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A SchifferUNKNOWN American Society of Clinical Oncology
May 9, 2001·Leukemia & Lymphoma·J B LawrenceH M Lazarus
Aug 25, 2001·Blood·L T GoodnoughS Armstrong
Nov 19, 2002·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marc S ZumbergJohn R Wingard
Jun 26, 2003·British Journal of Haematology·UNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
May 3, 1962·The New England Journal of Medicine·L A GAYDOSN MANTEL
Jan 31, 1963·The New England Journal of Medicine·I DJERASSIA E EVANS
Sep 16, 2004·Blood·Luc SensebéDelphine Senecal
Dec 9, 2004·Transfusion·Alan TinmouthDavid Sutton
Dec 31, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Charles Marc SamamaUNKNOWN Agence Française de Sécurité Sanitaire des Produits de Santé expert group
Jul 1, 2005·Transfusion·Beatrice DiedrichOlle Ringdén
Apr 19, 2006·Journal of Clinical Apheresis·Sherrill J Slichter
Feb 27, 2007·Transfusion·Joan Cid, Miguel Lozano
May 1, 2007·Transfusion·Shoshan NevoGeorgia B Vogelsang
Aug 30, 2007·Transfusion·Shoshan NevoGeorgia B Vogelsang
Citations
Apr 1, 2014·Langenbeck's Archives of Surgery·Benedikt ReichertHarald Schrem
Jan 31, 2012·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C MartinaudP Aguilon
Dec 22, 2015·Revista española de anestesiología y reanimación·J V LlauP Torrabadella
Feb 3, 2009·Clinics in Chest Medicine·Peter W Marks
Aug 4, 2015·Medicina intensiva·J V LlauP Torrabadella
Nov 3, 2010·Internal Medicine Journal·D C BuhrkuhlJ M Carter
May 25, 2010·Transfusion·D C Buhrkuhl
Dec 18, 2013·Vox Sanguinis·M LozanoUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Oct 7, 2009·Transfusion·Ravindra SarodeCynthia Rutherford
Dec 3, 2009·Transfusion·Joan CidAndreu Llorente
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sema Sezgin GoksuHasan Senol Coskun