Consensus guidelines for the use and interpretation of angiogenesis assays

Angiogenesis
Patrycja Nowak-SliwinskaArjan W Griffioen

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

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Citations

Aug 14, 2018·The Journal of Pathology·Victor Ljl ThijssenArjan W Griffioen
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Methods Mentioned

BETA
transgenic
dissection
Assay
phase-contrast microscopy
dissect
transmission electron microscopy
electron microscopy
dissecting
light microscopy
imaging techniques

Software Mentioned

Adobe Photoshop
SeedLink
Volocity
Metabolomics
NIH
Imaris
Fiji
IncuCyte
SWIFT
Google Scholar

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