Consensus interferon plus ribavirin for hepatitis C genotype 3 patients previously treated with pegylated interferon plus ribavirin

Hepatitis Monthly
Zaigham AbbasSaeed Hamid

Abstract

Not enough data are available about the effectiveness of consensus interferon (CIFN) among HCV genotype 3 patients who failed to respond to pegylated interferon and ribavirin. We aimed to assess the efficacy and safety of CIFN and ribavirin in non-responders and relapsers to pegylated interferon with ribavirin therapy. This open-label investigator-initiated study included 44 patients who received CIFN 15 µg /day plus ribavirin 800-1200 mg daily. In patients with an early virological response (EVR), the dose of CIFN was reduced to 15 µg thrice a week for further 36 weeks. Patients with delayed virological response continued to receive daily CIFN plus ribavirin to complete 48 weeks. The patients were considered "non-responders" if there were less than 2 log reduction in HCV RNA at 12 weeks and detectable HCV RNA at 24 weeks. Twenty-four patients (55%) were non-responders and 20 patients were relapsers to the previous treatment with pegylated interferon plus ribavirin (mean age 43.6 ± 9.4 years, males 25 (57%)). Nine patients were clinically cirrhotic (Child A). End of treatment virological response was achieved in 19 (43.1%) patients and sustained virological response (SVR) occurred in 12 (27.3%). Out of these 12 patients, eight ...Continue Reading

References

Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Jul 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L M BlattM W Taylor
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteL M Blatt
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mitchell L Shiffman
Aug 29, 2003·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·David N MoskovitzE Jenny Heathcote
Dec 10, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Lucia MiglioresiGiovanni L. Ricci
Mar 5, 2004·Annals of Internal Medicine·Stephanos J HadziyannisUNKNOWN PEGASYS International Study Group
Oct 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmet B Keeffe
Apr 6, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Wulf O BöcherPeter R Galle
Jul 18, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Barbara HöroldtDavid Mutimer
Jun 7, 2007·World Journal of Gastroenterology : WJG·Miriam J Alter
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce R BaconNorman Gitlin
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Nov 3, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Alessandra Mangia
Feb 22, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·UNKNOWN U.S. Department of Health and Human Services
Mar 5, 2011·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Sep 1, 2011·Digestive Diseases and Sciences·Christopher M MooreDavid H Van Thiel
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for Study of Liver Diseases

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Citations

Oct 8, 2019·Biotechnology and Applied Biochemistry·Fakiha BajwaAhmad Usman Zafar

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Methods Mentioned

BETA
PCR
genotyping
biopsy
biopsies

Software Mentioned

SPSS
METAVIR

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