Consequence of Elevated Fibroblast Growth Factor 23 Levels in Acute Kidney Injury, Renal Recovery and Overall Survival in Intensive Care Unit Patients After Major Surgery

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Sanja SakanNikolina Basic-Jukic

Abstract

The main goal of our study was to investigate the role of increased fibroblast growth factor 23 (FGF23) levels on renal recovery and overall survival. We conducted a prospective case-control cohort study, which included 121 adult cases who developed AKI after major surgical procedures. The subjects were followed-up until the last enrolled patient survived 180 days or until the time of death. Higher FGF23 levels positively correlated with serum creatinine levels (P < 0.05). Significantly higher number of patients without diuresis and with FGF23 ≤ 709 RU/mL survived when compared to patients without diuresis and with FGF23 ≥ 709 RU/mL (P < 0.001). FGF23 levels >709 RU/mL were a good predictive tool for overall mortality in a 6-month period (P < 0.05). This is the first study to analyze the impact of FGF23 values on short-term renal recovery and survival of patients with AKI after major surgery. The FGF23 increase related to AKI especially in more severe stages and in patients without diuresis is an independent risk factor for mortality.

References

Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Katherine Wesseling-PerryIsidro B Salusky
Dec 1, 2009·Kidney International. Supplement·Sarah SeilerDanilo Fliser
Jun 19, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Edward D SiewLorraine B Ware
Aug 28, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Jay L KoynerPatrick T Murray
Aug 24, 2011·International Journal of Nephrology·Kathryn K StevensAlan G Jardine
Sep 13, 2011·Annals of Intensive Care·Maryann ZhangKathleen D Liu
Jun 16, 2012·Clinical Journal of the American Society of Nephrology : CJASN·David E LeafLeonard Stern
Sep 22, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Abigail May KhanSylvia E Rosas
Jan 15, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Farah N AliCraig B Langman
Feb 28, 2013·American Journal of Physiology. Endocrinology and Metabolism·Chad D TouchberryMichael J Wacker
May 10, 2013·Kidney International·Marta ChristovHarald Jüppner
Dec 19, 2014·Journal of Intensive Care·Sham SunderPranit Ram
Jul 15, 2015·Intensive Care Medicine·M SchetzG Van den Berghe
Sep 17, 2016·American Journal of Respiratory and Critical Care Medicine·John A KellumLakhmir S Chawla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.