PMID: 9536844Apr 16, 1998Paper

Consequences for fetus and neonate of maternal red cell allo-immunisation

Archives of Disease in Childhood. Fetal and Neonatal Edition
H HowardJ Eggington

Abstract

To study the distribution of clinically important red cell antibodies in pregnancy, and the associated fetal and neonatal morbidity and mortality. The case notes of women with clinically important red cell antibodies identified in their serum during pregnancy were reviewed. During a 12 month period 22,264 women were referred for antenatal screening. Clinically important red cell antibodies were detected in 244 (1%). Of these, 100 were anti-D and 144 were non-RhD antibodies. There were three intrauterine deaths, three fetuses required intrauterine transfusion, 10 neonates were transfused, 27 others had phototherapy, and 27 with a positive direct antiglobulin test received no treatment. Early fetal losses occurred in the presence of both high and low levels of anti-D. Anti-D remains the most common clinically important antibody in pregnancy, and accounts for the greatest fetal and neonatal morbidity and mortality. Of the other antibodies detected, anti-c was associated with most neonatal morbidity. The production of many of the non-D antibodies detected could be avoided by the use of selected red cells when transfusing pre-menopausal women.

References

May 2, 1992·BMJ : British Medical Journal·K H Nicolaides, C H Rodeck
Jul 1, 1994·American Journal of Obstetrics and Gynecology·J I VaughanN M Fisk
Apr 1, 1993·Transfusion·P D IssittJ Bumgarner
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Citations

Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neil A Murray, Irene A G Roberts
Dec 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·R Gottstein, R W I Cooke
Jul 16, 2008·Early Human Development·Irene A G Roberts
Sep 1, 2015·La Presse médicale·Claudine Le VaillantAnne-Sophie Riteau
Aug 8, 2007·Transfusion Medicine·UNKNOWN British Committee for Standards in Haematology Blood Transfusion Task ForceH Qureshi
Jul 19, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Meena SidhuVijay Sawhney
Apr 23, 2015·Vox Sanguinis·M de HaasC E van der Schoot
Apr 15, 2016·Transfusion Medicine·J WhiteUNKNOWN British Committee for Standards in Haematology
May 18, 2007·American Journal of Medical Genetics. Part a·Judith H Miles, T Nicole Takahashi
Jan 6, 2004·Obstetrics and Gynecology·David N HackneyRichard W O'Shaughnessy
Jan 21, 2020·Transfusion Medicine·Michael FarrellJudith Hannon
Apr 17, 2003·The Journal of Obstetrics and Gynaecology Research·William W K ToKa Ming Mok
Dec 18, 2019·BMJ Case Reports·Soumya DasPoornima B Baliga
Aug 10, 2020·Transfusion·Naomi Rahimi-LeveneUNKNOWN Israeli HDFN Study Group Investigators
Jun 10, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Soumya DasShamee Shastry

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