Consequences of a high phosphorus intake on mineral metabolism and bone remodeling in dependence of calcium intake in healthy subjects - a randomized placebo-controlled human intervention study

Nutrition Journal
Ulrike TrautvetterMichael Glei

Abstract

Epidemiological studies reported an association between plasma phosphate concentrations and a higher risk for death and cardiovascular events in subjects free of chronic kidney diseases. The main aims of the present study were to determine the influence of a high phosphorus intake in combination with different calcium supplies on phosphorus, calcium, magnesium and iron metabolism as well as fibroblast growth factor 23 (FGF23) concentrations within eight weeks of supplementation. Sixty-two healthy subjects completed the double-blind, placebo-controlled parallel designed study. Supplements were monosodium phosphate and calcium carbonate. During the first two weeks, all groups consumed a placebo sherbet powder, and afterwards, for eight weeks, a sherbet powder according to the intervention group: P1000/Ca0 (1 g/d phosphorus), P1000/Ca500 (1 g/d phosphorus and 0.5 g/d calcium) and P1000/Ca1000 (1 g/d phosphorus and 1 g/d calcium). Dietary records, fasting blood samplings, urine and fecal collections took place. Fasting plasma phosphate concentrations did not change after any intervention. After all interventions, renal excretions and fecal concentrations of phosphorus increased significantly after eight weeks. Renal calcium and mag...Continue Reading

Associated Clinical Trials

Mar 24, 2014·Prof. Dr. Michael Glei

References

Jan 1, 1991·The American Journal of Clinical Nutrition·J D CookP Whittaker
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Kärkkäinen, C Lamberg-Allardt
Mar 3, 1998·European Journal of Clinical Nutrition·A WhybroR Eastell
Jul 17, 1998·The American Journal of Clinical Nutrition·A M Minihane, S J Fairweather-Tait
Dec 23, 2004·The Journal of Clinical Endocrinology and Metabolism·Serge L FerrariRené Rizzoli
Jul 1, 2005·The Journal of Nutrition·Bianka DitscheidGerhard Jahreis
Oct 26, 2005·Circulation·Marcello TonelliUNKNOWN Cholesterol And Recurrent Events Trial Investigators
Jul 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sherri -Ann M BurnettJoel S Finkelstein
May 16, 2007·Archives of Internal Medicine·Ravi DhingraRamachandran S Vasan
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf
Dec 17, 2008·Journal of the American Society of Nephrology : JASN·Kathryn L AdeneyBryan R Kestenbaum
May 2, 2009·Journal of the American Society of Nephrology : JASN·Emi ShutoEiji Takeda
Oct 29, 2009·The British Journal of Nutrition·Karima BenkheddaKevin A Cockell
Oct 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Marc G VervloetPiet M ter Wee
Feb 25, 2011·Kidney International. Supplement·Harald Jüppner
Oct 25, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ulrike TrautvetterGerhard Jahreis
Jul 6, 2012·European Journal of Nutrition·Heini J KarpMerja U M Kärkkäinen
Oct 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mhairi SigristAdeera Levin
Jan 3, 2013·Seminars in Dialysis·Mona S Calvo, Jaime Uribarri
Sep 17, 2013·Advances in Nutrition·Jaime Uribarri, Mona S Calvo
Nov 15, 2013·The American Journal of Clinical Nutrition·Alex R ChangMorgan E Grams
Mar 4, 2014·Annals of Clinical Biochemistry·P ManghatR Swaminathan
Jun 29, 2014·The Journal of Physiology·Eleanor Lederer
Apr 1, 2011·Kidney International·Harald Jüppner

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Citations

Aug 16, 2018·Physiological Reviews·Toshimi MichigamiKeiichi Ozono
Apr 12, 2019·Frontiers in Endocrinology·Toshimi Michigami, Keiichi Ozono
Nov 30, 2018·Biological Trace Element Research·Forrest H Nielsen
Oct 8, 2020·International Journal of Environmental Research and Public Health·Josep PenuelasJordi Sardans
Sep 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Allison Cooke
Aug 28, 2021·The Journal of Clinical Endocrinology and Metabolism·Christin VolkGabriele I Stangl
Jun 8, 2017·Diabetes Spectrum : a Publication of the American Diabetes Association·David E St-JulesMary Ann Sevick

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Clinical Trials Mentioned

NCT02095392

Software Mentioned

SPSS Statistics
Prodi®

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