Consequences of alteration in capillary permeability

Canadian Journal of Physiology and Pharmacology
G E PlantePierre Sirois

Abstract

In this review paper, three aspects related to alteration in capillary permeability, based on a series of recent observations from this laboratory, are examined. Firstly, the determinants of capillary extravasation, which include pre- and post-capillary resistances in different microcirculation networks, as well as endothelial permeability per se, are described with particular reference to the heterogeneous character of both regulatory components, reported by this and other groups. Secondly, the endothelium-interstitium relationship, responsible in part for the maintenance of the interstitial compartment physicochemical characteristics, is introduced as an important factor in regulating the traffic of vital nutrients delivered to the cell mass, and the removal of waste products from the cellular compartment to the microcirculation, for ultimate excretion. Examined in this manner, it appears that modulation of capillary permeability is essential for the maintenance of cellular life, yet the neurohumoral mechanisms involved in the control of microcirculation networks are just starting to be identified. A number of morbid conditions characterized by multiorgan involvement exhibit a common pathophysiological denominator which invol...Continue Reading

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Citations

Dec 5, 2002·European Journal of Pharmacology·Bichoy H Gabra, Pierre Sirois
Mar 15, 2003·Neuropeptides·Bichoy H Gabra, Pierre Sirois
Jun 24, 1999·The Journal of Urology·D E BjorlingR Saban
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Jul 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zheng FanWilliam Powers
Oct 20, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S KelekciS Sonmez
Aug 23, 2000·Medicina clínica·A Fernández-FúnezA Hernández
May 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·R HimesG J Russell-Jones
Feb 9, 2005·British Journal of Pharmacology·Julie KeebleSusan Diana Brain
Sep 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevsen KulaksizogluSuna Turkoglu
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Dec 8, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·P HannaertR P Garay
Mar 22, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·T HattoriM Akimoto
Mar 16, 2005·Skin Pharmacology and Physiology·K Kretsos, G B Kasting

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