Abstract
In this review paper, three aspects related to alteration in capillary permeability, based on a series of recent observations from this laboratory, are examined. Firstly, the determinants of capillary extravasation, which include pre- and post-capillary resistances in different microcirculation networks, as well as endothelial permeability per se, are described with particular reference to the heterogeneous character of both regulatory components, reported by this and other groups. Secondly, the endothelium-interstitium relationship, responsible in part for the maintenance of the interstitial compartment physicochemical characteristics, is introduced as an important factor in regulating the traffic of vital nutrients delivered to the cell mass, and the removal of waste products from the cellular compartment to the microcirculation, for ultimate excretion. Examined in this manner, it appears that modulation of capillary permeability is essential for the maintenance of cellular life, yet the neurohumoral mechanisms involved in the control of microcirculation networks are just starting to be identified. A number of morbid conditions characterized by multiorgan involvement exhibit a common pathophysiological denominator which invol...Continue Reading
References
Feb 11, 1992·Circulation Research·D J Meyer, V H Huxley
Sep 1, 1992·The Journal of Clinical Investigation·S LamasP A Marsden
Dec 1, 1992·British Journal of Pharmacology·S LehouxP D'Orléans-Juste
Apr 22, 1992·European Journal of Pharmacology·M G SiroisP Sirois
Jun 1, 1992·The Journal of Clinical Investigation·G E PlanteP Sirois
Jul 1, 1992·Circulation·P J FitzgeraldP G Yock
Aug 1, 1992·The Journal of Experimental Zoology·E H Hanneman
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Feb 1, 1991·The Journal of Clinical Investigation·R BucalaA Cerami
Mar 1, 1991·Kidney International·K V Lemley, W Kriz
Dec 1, 1990·British Journal of Pharmacology·M G SiroisP Sirois
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R B Wysolmerski, D Lagunoff
Jul 1, 1989·Journal of Pharmacological Methods·D F RogersP J Barnes
Sep 29, 1986·Life Sciences·F A AlmeidaT Maack
Feb 1, 1987·Circulation Research·V H HuxleyR H Freeman
Mar 1, 1986·Circulation Research·D M Gawlowski, W N Durán
Jan 1, 1987·Annual Review of Biochemistry·M J Berridge
Jul 1, 1987·The Journal of Physiology·C C Michel, M E Phillips
May 24, 1973·The New England Journal of Medicine·K DikshitH J Swan
Sep 1, 1983·Medicine·A Verghese, S L Berk
Oct 1, 1984·Kidney International·M BrezisF H Epstein
Jul 22, 1982·The New England Journal of Medicine·R J BrennerR C Morris
Apr 15, 1994·European Journal of Pharmacology·R S BoydJ MacDermot
Jan 1, 1994·European Journal of Pharmacology·M W BeukersW Soudijn
Dec 1, 1993·Kidney International·D SorbiL Arbeit
Mar 1, 1993·The Journal of Experimental Zoology·J M Bedford, H H Kim
Oct 4, 1995·European Journal of Pharmacology·M ChakirG E Plante
Aug 1, 1959·The American Journal of Medicine·I S EDELMAN, J LEIBMAN
Citations
Nov 13, 2003·Peptides·Bichoy H Gabra, Pierre Sirois
Dec 5, 2002·European Journal of Pharmacology·Bichoy H Gabra, Pierre Sirois
Mar 15, 2003·Neuropeptides·Bichoy H Gabra, Pierre Sirois
Jun 24, 1999·The Journal of Urology·D E BjorlingR Saban
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Apr 11, 2003·Molecular Biology of the Cell·François HouleJacques Huot
Jul 21, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zheng FanWilliam Powers
Oct 20, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S KelekciS Sonmez
Aug 23, 2000·Medicina clínica·A Fernández-FúnezA Hernández
May 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·R HimesG J Russell-Jones
Feb 9, 2005·British Journal of Pharmacology·Julie KeebleSusan Diana Brain
May 10, 2005·European Journal of Pharmacology·Sibi R LawsonPierre Sirois
Sep 8, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevsen KulaksizogluSuna Turkoglu
Mar 20, 2001·Microvascular Research·S C ChenR C Yang
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Jan 5, 2002·Diabetes/metabolism Research and Reviews·G LetoG Pugliese
Nov 20, 2003·Shock·Jan SchumacherKarl-Friedrich Klotz
Mar 8, 2016·Journal of Wound Care·K OuseyM G Rippon
Jul 11, 2014·Circulation Research·Glenn C RoweZolt Arany
Sep 2, 2000·Circulation Research·S Y YuanA C Taulman
Sep 15, 2005·Circulation·Leonard T SuHansell H Stedman
Dec 8, 1998·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·P HannaertR P Garay
Mar 22, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·T HattoriM Akimoto
Mar 16, 2005·Skin Pharmacology and Physiology·K Kretsos, G B Kasting
Sep 8, 2010·Fetal Diagnosis and Therapy·L RodeA Tabor
Apr 6, 2007·Cancer Research·Dan Liu, Peter J Hornsby