PMID: 6170390Nov 23, 1981Paper

Consequences of axonal transport blockade by batrachotoxin on mammalian neuromuscular junction. II. Late pre- and postsynaptic changes

Brain Research
S S DeshpandeE X Albuquerque

Abstract

The present study describes the time course of recovery in the fast axonal transport of 3H-labeled proteins in the nerve and the electrophysiological parameters in the extensor muscle of rats after single subperineural injection of batrachotoxin (BTX) (9.3 x 10(-12) mol) into the peroneal nerve. The fast axonal transport of 3H-labeled proteins in the sciatic nerve showed significant accumulation of the labeled proteins proximal to the site of BTX injection at day 2. However, by day 7, when no locomotor deficit was visible, complete recovery of fast axonal transport had occurred. The recovery of membrane potential in this surface fibers of the extensor muscle, which showed atrophy even after 22 days of toxin administration, lagged far behind the recovery in the fast axonal transport. Between day 2 and 14 the extensor muscle showed partial membrane depolarization with almost complete recovery by day 22. From 18 h to 7 days after subperineural BTX injection, spontaneous (m.e.p.p.s.) or nerve evoked transmitter release were absent at the endplates of the affected extensor muscles. M.e.p.p.s. of very low frequency began to appear between day 7 and 10. Even at days 14 and 22, when most of the fibers tested showed m.e.p.p.s, the frequ...Continue Reading

References

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