Consequences of chemotherapy on resection of colorectal liver metastases

Journal of Visceral Surgery
P PessauxDaniel Jaeck

Abstract

The response rate of colorectal metastases to chemotherapy, ranging from 50 to 60%, has been shown to be a prognostic factor. Complete pathologic and radiological response rates are approximately 4 and 7%, respectively. Hepatotoxic effects of oxaliplatin and irinotecan on the non-tumoral liver parenchyma have been reported and are incriminated in vascular changes (sinusoidal obstruction syndrome [SOS]) and chemotherapy-associated steatohepatitis (CASH). Oxaliplatin-based regimens are associated with an increased risk of vascular lesions and irinotecan-based regimens are associated with increased risks of steatosis and steatohepatitis. SOS increases morbidity after major liver resection, mostly after administration of more than six cycles of neoadjuvant systemic chemotherapy. CASH increases morbidity and mortality rates after hepatectomy. Preliminary results have shown that the addition of targeted molecular therapy (bevacizumab or cetuximab) to conventional chemotherapy does not increase the postoperative morbidity or mortality rates after hepatectomy and does not create additional injury to the non-tumoral liver parenchyma. However, bevacizumab may impair regeneration of the future remnant. Chemotherapy may reduce the sensitiv...Continue Reading

References

Aug 1, 1989·Annals of Surgery·G Steele, T S Ravikumar
Jul 1, 1996·Seminars in Surgical Oncology·Y FongA M Cohen
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K E BehrnsD M Nagorney
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L D DeLeveG C Kanel
Aug 12, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GiacchettiF Lévi
Mar 4, 2000·AJR. American Journal of Roentgenology·G T SicaP R Ros
Jul 18, 2000·Journal of the American College of Surgeons·J BelghitiO Farges
Dec 26, 2001·Bone Marrow Transplantation·R M Szydlo
Apr 3, 2002·Seminars in Liver Disease·Laurie D DeLeveGeorge B McDonald
Nov 15, 2002·Diseases of the Colon and Rectum·Nobutomo MiyanariMasamichi Yasuno
Feb 1, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter J AllenYuman Fong
Feb 8, 2003·Science·Jennifer LeCouterNapoleone Ferrara
Mar 13, 2003·Radiologic Clinics of North America·Ihab R Kamel, David A Bluemke
Mar 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L Rubbia-BrandtB Terris
Mar 30, 2004·Journal of Surgical Oncology·Dominique EliasMichel Ducreux
May 21, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PozzoC Barone
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Glenn TismanAshley Plant
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory D LeonardNancy E Kemeny
May 5, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FolprechtC-H Köhne
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 1, 2005·Journal of the American College of Surgeons·Felix G FernandezSteven M Strasberg
Oct 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven R AlbertsJohn H Donohue
Dec 24, 2005·Annals of Surgery·Yuman Fong, David J Bentrem
Mar 1, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Diane GoéréJacques Belghiti
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyEddie K Abdalla
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Carl Jaffe
Aug 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stéphane BenoistBernard Nordlinger
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas AloiaRené Adam

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Citations

Mar 28, 2013·International Journal of Hepatology·Eric Nguyen-KhacJean Marc Regimbeau
Feb 9, 2012·International Journal of Surgical Oncology·Ashraf J HaddadSteven C Cunningham
Feb 14, 2013·The British Journal of Radiology·H NilssonE Jonas
Oct 17, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Paramin MuangkaewSeong Uk Kwon
Mar 12, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Reza KianmaneshDaniele Sommacale
Sep 12, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D J EversT J M Ruers
Mar 20, 2012·Critical Reviews in Oncology/hematology·Steven R Alberts
Dec 24, 2011·Clinical Colorectal Cancer·Thomas H Cartwright
Oct 10, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Henrik NilssonEduard Jonas
Jan 15, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Petra G KeleMarieke T de Boer
Aug 11, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kim M C van MierloSteven W M Olde Damink
Jul 9, 2014·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Antonio Nocchi KalilCristiane Becker Neutzling
Nov 19, 2017·Langenbeck's Archives of Surgery·Sarah Walcott-Sapp, Kevin G Billingsley
Mar 24, 2012·Digestive Surgery·Alfredo GuglielmiCalogero Iacono
Jan 27, 2016·World Journal of Gastroenterology : WJG·Rafif E MattarMazen Hassanain
Aug 20, 2016·Clinical & Experimental Metastasis·Olga Golubnitschaja, Krishna Chander Sridhar
Oct 27, 2018·World Journal of Gastrointestinal Oncology·Emilio De RaffeleFrancesco Minni
Jul 17, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·K F FlickM G House
May 24, 2019·Journal of Lasers in Medical Sciences·Tiago Gomes AraújoAntonio R Franchi Teixeira

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