Consequences of Disrupted Notch Signaling in Bladder Cancer

European Urology
Annemarie GreifeWolfgang A Schulz

Abstract

The Notch pathway, which controls stem cell maintenance and cell differentiation, is activated in certain cancers and therefore constitutes a therapeutic target. Especially in invasive urothelial carcinoma, the pathway is inactivated instead, and drugs inhibiting Notch signaling are likely contra-indicated.

References

Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Wolfgang A Schulz
Dec 8, 2010·Virchows Archiv : an International Journal of Pathology·Nadine T GaisaRuth Knuechel
Feb 9, 2012·Seminars in Cell & Developmental Biology·Casper Groth, Mark E Fortini
Jul 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ann Marie Egloff, Jennifer R Grandis
Mar 6, 2013·Pharmacology & Therapeutics·Ingrid Espinoza, Lucio Miele
Jun 1, 2014·European Urology·David J McConkeyColin P N Dinney
Sep 10, 2014·Nature Medicine·Theodoros RampiasApostolos Klinakis
Jan 13, 2015·The Journal of Clinical Investigation·Antonio MaraverManuel Serrano

❮ Previous
Next ❯

Citations

Jun 29, 2016·Journal of Oral Science·Thanaphum OsathanonPrasit Pavasant
Jul 12, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Dong Fang, Hiroshi Kitamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Advances in Experimental Medicine and Biology
M LiebertH B Grossman
Oncotarget
Pablo J Fernandez-MarcosAntonio Maraver
Analytical and Quantitative Cytology and Histology
Antonio Lopez-Beltran
© 2021 Meta ULC. All rights reserved