Consequences of Location-Dependent Organ of Corti Micro-Mechanics

PloS One
Yanju LiuJong-Hoon Nam

Abstract

The cochlea performs frequency analysis and amplification of sounds. The graded stiffness of the basilar membrane along the cochlear length underlies the frequency-location relationship of the mammalian cochlea. The somatic motility of outer hair cell is central for cochlear amplification. Despite two to three orders of magnitude change in the basilar membrane stiffness, the force capacity of the outer hair cell's somatic motility, is nearly invariant over the cochlear length. It is puzzling how actuators with a constant force capacity can operate under such a wide stiffness range. We hypothesize that the organ of Corti sets the mechanical conditions so that the outer hair cell's somatic motility effectively interacts with the media of traveling waves-the basilar membrane and the tectorial membrane. To test this hypothesis, a computational model of the gerbil cochlea was developed that incorporates organ of Corti structural mechanics, cochlear fluid dynamics, and hair cell electro-physiology. The model simulations showed that the micro-mechanical responses of the organ of Corti are different along the cochlear length. For example, the top surface of the organ of Corti vibrated more than the bottom surface at the basal (high fre...Continue Reading

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Citations

Jan 7, 2016·Nature Communications·Tianying RenPeter G Barr-Gillespie
Aug 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tianying RenDavid Kemp
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hamid MotallebzadehSunil Puria
Sep 11, 2020·Scientific Reports·Mohammad ShokrianJong-Hoon Nam
Sep 8, 2017·PLoS Computational Biology·Yanju LiuJong-Hoon Nam
Mar 3, 2018·The Journal of the Acoustical Society of America·Daniel MarnellJong-Hoon Nam
Oct 21, 2020·Scientific Reports·Amir NankaliKarl Grosh
Feb 8, 2018·Biophysical Journal·Thomas Bowling, Julien Meaud

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