Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats

Behavioural Brain Research
Jana D TchekalarovaNikolai Lazarov

Abstract

Previous data have shown that the rat model of melatonin deficit can cause a number of neurobiological aberrations. The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, biochemical and cellular abnormalities induced by pinealectomy. The injection of agomelatine (40 mg/kg, i.p. for 5 weeks)/vehicle started after pinealectomy/sham procedure in Wistar rats. Animals were tested in different behavioral tests for anxiety and depression during the period of agomelatine treatment (chronic effect) and two months later (plastic effect). The effect of agomelatine on KCl-evoked serotonin (5-HT) release from the hippocampus, the activity of the hypothalamic-pituitary-adrenal (HPA) axis and neuronal loss in pinealectomized rats were assessed. Our results showed that agomelatine not only did not prevent the disturbed emotional arousal/anxiety behavior in pinealectomized rats during the treatment but the enhanced motor activity and decreased anxiety state was still observed two months after the discontinuation of treatment. However, the drug corrected a depressive-like behavior (chronic and plast...Continue Reading

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Citations

Jun 18, 2016·British Journal of Pharmacology·Ralf JockersDarius P Zlotos
Jun 11, 2020·Archives of Physiology and Biochemistry·Saptadip Samanta
Jul 11, 2018·International Journal of Molecular Sciences·Slavianka MoyanovaJane Tchekalarova
Mar 25, 2018·IUBMB Life·Antonio Luiz Gomes JúniorAna Amélia de Carvalho Melo-Cavalcante

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