Consequences of mutation accumulation for growth performance are more likely to be resource-dependent at higher temperatures.

BMC Ecology and Evolution
Xiao-Lin Chu, Quan-Guo Zhang

Abstract

Mutation accumulation (MA) has profound ecological and evolutionary consequences. One example is that accumulation of conditionally neutral mutations leads to fitness trade-offs among heterogenous habitats which cause population divergence. Here we suggest that temperature, which controls the rates of all biochemical and biophysical processes, should play a crucial role for determining mutational effects. Particularly, warmer temperatures may mitigate the effects of some, not all, deleterious mutations and cause stronger environmental dependence in MA effects. We experimentally tested the above hypothesis by measuring the growth performance of ten Escherichia coli genotypes on six carbon resources across ten temperatures, where the ten genotypes were derived from a single ancestral strain and accumulated spontaneous mutations. We analyzed resource dependence of MA consequences for growth yields. The MA genotypes typically showed reduced growth yields relative to the ancestral type; and the magnitude of reduction was smaller at intermediate temperatures. Stronger resource dependence in MA consequences for growth performance was observed at higher temperatures. Specifically, the MA genotypes were more likely to show impaired grow...Continue Reading

References

Sep 1, 1993·The Journal of Heredity·M LynchW Gabriel
Feb 25, 2000·Proceedings. Biological Sciences·S Goho, G Bell
Jun 30, 2001·Evolution; International Journal of Organic Evolution·V S CooperR E Lenski
Oct 27, 2001·Science·J Peñuelas, I Filella
Aug 3, 2005·Nature Reviews. Genetics·Mark A DePristoDaniel L Hartl
Oct 15, 2005·The American Naturalist·Rowan D H BarrettGraham Bell
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrew P AllenJames H Brown
Oct 4, 2006·Proceedings. Biological Sciences·Alex R Hall, Nick Colegrave
Jan 9, 2007·The American Naturalist·Elizabeth A OstrowskiRichard E Lenski
Apr 14, 2007·Science·Richard A Kerr
Jun 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zachary D BlountRichard E Lenski
Aug 19, 2008·The American Naturalist·R Craig MacLean, Graham Bell
Jul 1, 1993·The American Naturalist·R E Lenski, A F Bennett
Jun 12, 2010·Trends in Ecology & Evolution·Aneil F Agrawal, Michael C Whitlock
Nov 26, 2010·Proceedings. Biological Sciences·Jennifer M SundayNicholas K Dulvy
Mar 17, 2012·Molecular Ecology·Jill T AndersonThomas Mitchell-Olds
Jun 2, 2012·Biochimie·Melike Cağlayan, Neş'e Bilgin
Nov 12, 2013·Evolution; International Journal of Organic Evolution·Alethea D WangAneil F Agrawal
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Ryan T HietpasDaniel N A Bolon
Nov 18, 2014·Global Change Biology·Wyatt F CrossDaniel Nelson
Jan 24, 2015·The American Naturalist·Leigh C LattaSarah Schaack
Dec 1, 1999·Evolution; International Journal of Organic Evolution·Ryszard Korona
Feb 1, 1996·Evolution; International Journal of Organic Evolution·Judith A MongoldRichard E Lenski
Aug 7, 2017·Nature Ecology & Evolution·Csaba Pál, Balázs Papp
Aug 29, 2018·Proceedings of the National Academy of Sciences of the United States of America·Luca Agozzino, Ken A Dill
Oct 20, 2018·International Journal of Molecular Sciences·Hendry SusilaJi Hoon Ahn
Nov 6, 2018·Nature Reviews. Genetics·Joshua L Payne, Andreas Wagner
Feb 3, 2021·Proceedings. Biological Sciences·David BergerRichard J Walters
Mar 18, 2021·Trends in Ecology & Evolution·Angela McGaughranCeridwen Fraser
Mar 23, 2021·Evolution; International Journal of Organic Evolution·Elizabeth S DavenportJeffry L Dudycha

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