PMID: 9169828Mar 15, 1997Paper

Consequences of optimization in PDR brachytherapy--is a routine geometrical optimization recommendable?

International Journal of Radiation Oncology, Biology, Physics
C BernsM Wannenmacher

Abstract

On the basis of clinical examples for interstitial volume implants and surface molds the benefit and disadvantage of optimization in pulsed dose rate (PDR) brachytherapy using a stepping source was investigated. Geometrically optimized PDR dose distributions were compared with nonoptimized ones as produced by Ir wires. In 25 patients who were treated with a double-plane interstitial breast implant with flexible catheters the first smoothly surrounding isodose, the reference volume and the uniformity and quality index derived from natural dose-volume histograms (Anderson) were considered. The effect of geometrical optimization on surface molds, which were used to irradiate chest wall relapses from breast cancer, was investigated by analyzing the reference surface, dose profiles, and depth-dose curves of a source arrangement covering an area of 10 x 10 cm2. Only in 3 of 25 patients the dose distribution of the volume implant was worsened by geometrical volume optimization regarding the homogeneity or the first smoothly surrounding isodose. Predominantly geometrical volume optimization reduced underdosage at the edges of the implants and improved the dose uniformity. The reference volume was increased. The geometrical distance opt...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·S DelanianF Baillet
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·E ArmourA Martinez
Jan 1, 1991·International Journal of Radiation Oncology, Biology, Physics·D J Brenner, E J Hall
Nov 1, 1986·Medical Physics·L L Anderson
Feb 1, 1994·International Journal of Radiation Oncology, Biology, Physics·K A MasonN Janjan
Apr 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P FritzM Flentje

❮ Previous
Next ❯

Citations

Aug 5, 1998·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·P FritzK J Weber
Nov 19, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P FritzM Wannenmacher
Feb 12, 2008·International Journal of Radiation Oncology, Biology, Physics·Kees KoedooderLeo E C M Blank

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P FritzM Wannenmacher
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
I K Kolkman-DeurlooP C Levendag
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Didier PeiffertJ J Mazeron
International Journal of Radiation Oncology, Biology, Physics
C de PreeJ M Kurtz
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Y AnacakA Haydaroğlu
© 2021 Meta ULC. All rights reserved