Consequences of recombination rate variation on quantitative trait locus mapping studies. Simulations based on the Drosophila melanogaster genome.

Genetics
M A NoorJ C Larkin

Abstract

We examine the effect of variation in gene density per centimorgan on quantitative trait locus (QTL) mapping studies using data from the Drosophila melanogaster genome project and documented regional rates of recombination. There is tremendous variation in gene density per centimorgan across this genome, and we observe that this variation can cause systematic biases in QTL mapping studies. Specifically, in our simulated mapping experiments of 50 equal-effect QTL distributed randomly across the physical genome, very strong QTL are consistently detected near the centromeres of the two major autosomes, and few or no QTL are often detected on the X chromosome. This pattern persisted with varying heritability, marker density, QTL effect sizes, and transgressive segregation. Our results are consistent with empirical data collected from QTL mapping studies of this species and its close relatives, and they explain the "small X-effect" that has been documented in genetic studies of sexual isolation in the D. melanogaster group. Because of the biases resulting from recombination rate variation, results of QTL mapping studies should be taken as hypotheses to be tested by additional genetic methods, particularly in species for which detail...Continue Reading

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A Coyne
Jan 25, 1983·Nucleic Acids Research·J C Larkin, J L Woolford
Apr 1, 1994·Genetics·Z B Zeng
Feb 1, 1996·Genetics·M W Nachman, G A Churchill
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·S V NuzhdinT F Mackay
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·G P CopenhaverD Preuss
Nov 3, 1998·Genetics·M W NachmanC F Aquadro
Feb 26, 2000·Genetical Research·H A Orr
Mar 25, 2000·Science·M D AdamsJ C Venter
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Aug 1, 1998·Evolution; International Journal of Organic Evolution·H Allen Orr
Jun 1, 1997·Evolution; International Journal of Organic Evolution·John R TrueCathy C Laurie

❮ Previous
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Citations

Oct 24, 2008·Phytopathology·Randall J WisserRebecca J Nelson
May 9, 2021·Molecular Biology and Evolution·Claire MérotLouis Bernatchez
Feb 2, 2002·Nature Reviews. Genetics·N H Barton, P D Keightley
Apr 22, 2005·The Journal of Heredity·C Lee
Feb 24, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·F A FeltusA H Paterson
May 11, 2005·Genetica·Patrick C Phillips
Apr 22, 2003·Evolution; International Journal of Organic Evolution·Arcadi Navarro, Nick H Barton
Sep 1, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Anna Westerbergh, John Doebley
Nov 17, 2007·Evolution; International Journal of Organic Evolution·Arianne Y K AlbertDolph Schluter
Dec 22, 2004·Genetica·A Susannah Boyle, Mohamed A F Noor
Dec 22, 2004·Genetics·Andrea J BetancourtH Allen Orr
Nov 1, 2002·Cell·Ana PeciñaAlain Nicolas
Jul 2, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Loren H RiesebergJohn M Burke
Oct 30, 2020·Journal of Evolutionary Biology·Emma L BerdanGenevieve M Kozak
Dec 19, 2002·Evolution; International Journal of Organic Evolution·Lila FishmanJohn H Willis
Sep 11, 2003·Proceedings. Biological Sciences·Maria R Servedio, Glenn-Peter Saetre
Oct 17, 2009·Nature Reviews. Genetics·Deborah Charlesworth, John H Willis
Oct 16, 2010·Science·Matthew V RockmanLeonid Kruglyak
Sep 15, 2010·Molecular Biology and Evolution·Diego AyalaFrédéric Simard
Oct 12, 2010·Current Opinion in Plant Biology·Katrin Hermann, Cris Kuhlemeier
Jan 18, 2008·Genome Research·Kevin BullaugheyGraham Coop
Apr 3, 2004·Genome Research·Michael I Jensen-SeamanHoward J Jacob
Mar 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Meredith E ProtasNipam H Patel
Apr 1, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Md Bazlur R Mollah, Akira Ishikawa

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