Conservation and divergence of ADAM family proteins in the Xenopus genome.

BMC Evolutionary Biology
Shuo WeiD W DeSimone

Abstract

Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The amphibian Xenopus has long been used as a model for early vertebrate development, but genome-wide analyses for large gene families were not possible until the recent completion of the X. tropicalis genome sequence and the availability of large scale expression sequence tag (EST) databases. In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species. Based on the X. tropicalis genome sequence and EST databases, we identified Xenopus orthologues of mammalian ADAMs and obtained full-length cDNA clones for these genes. The deduced protein sequences, synteny and exon-intron boundaries are conserved between most human and X. tropicalis orthologues. The alternative splicing patterns of certain Xenopus ADAM genes, such as adams 22 and 28, are similar to those of their mammalian orthologues. However, we were unable to identify an orthologue for ADAM7 or 8. The Xenopus orthologue of ADAM15, an active metalloproteinase in mammals, does not contain...Continue Reading

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Citations

Dec 24, 2011·Médecine sciences : M/S·Hélène Cousin, Dominique Alfandari
Aug 11, 2011·BMC Evolutionary Biology·Stefan KurtenbachEva M Neuhaus
Jul 20, 2012·The International Journal of Developmental Biology·Guofeng XuDouglas W DeSimone
May 12, 2012·Seminars in Cancer Biology·Pablo H Strobl-Mazzulla, Marianne E Bronner
Jan 10, 2012·Developmental Biology·Shuo WeiDouglas W DeSimone
Sep 27, 2013·Critical Reviews in Biochemistry and Molecular Biology·Laura ChristianShuo Wei
Jul 18, 2018·Indian Journal of Microbiology·Reshma TalkalHemant Purohit
Jan 2, 2019·Cellular and Molecular Life Sciences : CMLS·Sven ReinhardtKristina Endres

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Datasets Mentioned

BETA
BC146626
DQ287907
BC091726

Methods Mentioned

BETA
PCR

Software Mentioned

Protpars
Proml
Phylip application Seqboot
ClustalX
BLAT
Phylip neighbor
SignalP
Simple Modular Architecture Research Tool ( SMART )
Neighbor
Clustal

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