Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms.

Epigenetics & Chromatin
Ying-Jiun C Chen, Sharon Y R Dent

Abstract

The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone modifications, and interactions with transcription factors. Multiple lines of evidence indicate the existence of distinct variants of SAGA among organisms as well as within a species, permitting diverse functions to dynamically regulate cellular pathways. Our co-expression analysis of genes encoding human SAGA components showed enrichment in reproductive organs, brain tissues and the skeletal muscle, which corresponds to their established roles in developmental programs, emerging roles in neurodegenerative diseases, and understudied functions in specific cell types. SAGA subunits modulate growth, development and response to various stresses from yeast to plants and metazoans. In metazoans, SAGA further participates in the regulation of differentiation and maturation of both innate and adaptive immune cells, and is associated with initiation and progression of diseases including a broad range of cancers. The evolutionary conservation of SAGA highlights its indispensable role in eukaryotic life, thus deciphering the mechanism...Continue Reading

References

Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·J E Brownell, C D Allis
Sep 3, 1998·The Journal of Biological Chemistry·E MartinezR G Roeder
Sep 22, 1999·Molecular and Cellular Biology·A EberharterJ L Workman
Dec 28, 1999·Molecular and Cellular Biology·S B McMahonM D Cole
Jul 9, 2002·Molecular and Cellular Biology·Pei-Yun Jenny Wu, Fred Winston
Aug 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·David E SternerShelley L Berger
Nov 26, 2002·Molecular and Cellular Biology·Marilyn G Pray-GrantPatrick A Grant
Dec 9, 2003·The Journal of Biological Chemistry·Jeremy A DanielPatrick A Grant
Dec 2, 2004·Molecular and Cellular Biology·Jagruti H PatelSteven B McMahon
Jun 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Vikas B PalhanRobert G Roeder
Sep 2, 2005·Molecular and Cellular Biology·Clément CarréChristophe Antoniewski
Sep 19, 2006·Molecular and Cellular Biology·Sebastián GuelmanJerry L Workman
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tangui MauriceCéline Gongora
Nov 21, 2007·Cell·C David AllisYi Zhang
Feb 17, 2009·The Journal of Biological Chemistry·Shanshan Li, Michael A Shogren-Knaak
Jun 6, 2009·The Journal of Biological Chemistry·Timothy J KellyPere Puigserver
Aug 18, 2009·Molecular Cell·Boyko S AtanassovSharon Y R Dent

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Software Mentioned

SAGA
Cancer Dependency Map ( DepMap
Ada3
R

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