Conservation and variability of hepatitis B core at different chronic hepatitis stages.

World Journal of Gastroenterology : WJG
Marçal YllFrancisco Rodríguez-Frías

Abstract

Since it is currently not possible to eradicate hepatitis B virus (HBV) infection with existing treatments, research continues to uncover new therapeutic strategies. HBV core protein, encoded by the HBV core gene (HBC), intervenes in both structural and functional processes, and is a key protein in the HBV life cycle. For this reason, both the protein and the gene could be valuable targets for new therapeutic and diagnostic strategies. Moreover, alterations in the protein sequence could serve as potential markers of disease progression. To detect, by next-generation sequencing, HBC hyper-conserved regions that could potentially be prognostic factors and targets for new therapies. Thirty-eight of 45 patients with chronic HBV initially selected were included and grouped according to liver disease stage [chronic hepatitis B infection without liver damage (CHB, n = 16), liver cirrhosis (LC, n = 5), and hepatocellular carcinoma (HCC, n = 17)]. HBV DNA was extracted from patients' plasma. A region between nucleotide (nt) 1863 and 2483, which includes HBC, was amplified and analyzed by next-generation sequencing (Illumina MiSeq platform). Sequences were genotyped by distance-based discriminant analysis. General and intergroup nt and a...Continue Reading

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Citations

Apr 22, 2021·Expert Review of Molecular Diagnostics·Selene Garcia-GarciaFrancisco Rodríguez-Frías

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Datasets Mentioned

BETA
PRJNA625435

Methods Mentioned

BETA
PCR
biopsy
Assay

Software Mentioned

hpl
R scripts

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