PMID: 6169840Sep 1, 1981Paper

Conservation and variation in the hemagglutinins of Hong Kong subtype influenza viruses during antigenic drift

Journal of Virology
G W Both, M J Sleigh

Abstract

The nucleotide sequence was determined for the hemagglutinin gene of the Hong Kong subtype influenza strain A/Bangkok/1/79. The amino acid sequence predicted from these data shows a total of 36 amino acid changes as compared with hemagglutinin for a 1968 Hong Kong strain, 11 more than had occurred in a 1975 strain. The distribution of these changes confirmed that there are conserved and highly variable regions in hemagglutinin as the viral gene evolves during antigenic drift in the Hong Kong subtype. Of the four variable regions found in this study, only two have been seen previously. Correlation of highly variable areas in the hemagglutinins of Hong Kong subtype field strains with sites of amino acid changes in antigenically distinct influenza variants enabled us to predict likely antigenic regions of the protein. The results support and extend similar predictions made recently, based on the three-dimensional arrangement of hemagglutinin from a 1968 influenza strain.

References

Apr 1, 1979·Nucleic Acids Research·M J SleighG G Brownlee
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 11, 1979·Nucleic Acids Research·R Staden
May 15, 1979·European Journal of Biochemistry·G W Both, G M Air
Nov 1, 1977·Nucleic Acids Research·R Staden
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J J Skehel, M D Waterfield
Aug 2, 1972·Nature: New Biology·C M Brand, J J Skehel

❮ Previous
Next ❯

Citations

Jan 1, 1985·Archives of Virology·C López-GalindezR Nájera
Mar 11, 1982·Nature·R G WebsterG C Schild
Jun 12, 1989·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J J SkehelP F Riska
Feb 1, 1983·Journal of Virology·M KrystalP Palese
Sep 1, 1982·Infection and Immunity·D C JacksonW U Gerhard
Feb 1, 1992·Journal of Virology·W J BeanR G Webster
Sep 1, 1994·Microbiological Reviews·J H Strauss, E G Strauss
Jun 1, 1983·Biochimie·J M Clément
Mar 26, 1982·Science·J HollandS VandePol
Mar 19, 1982·Science·P Palese, J F Young

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.