PMID: 9445004Jan 28, 1998Paper

Conservation of an intact vif gene of human immunodeficiency virus type 1 during maternal-fetal transmission

Journal of Virology
V R YedavalliN Ahmad

Abstract

The human immunodeficiency virus type 1 (HIV-1) vif gene is conserved among most lentiviruses, suggesting that vif is important for natural infection. To determine whether an intact vif gene is positively selected during mother-to-infant transmission, we analyzed vif sequences from five infected mother-infant pairs following perinatal transmission. The coding potential of the vif open reading frame directly derived from uncultured peripheral blood mononuclear cell DNA was maintained in most of the 78,912 bp sequenced. We found that 123 of the 137 clones analyzed showed an 89.8% frequency of intact vif open reading frames. There was a low degree of heterogeneity of vif genes within mothers, within infants, and between epidemiologically linked mother-infant pairs. The distances between vif sequences were greater in epidemiologically unlinked individuals than in epidemiologically linked mother-infant pairs. Furthermore, the epidemiologically linked mother-infant pair vif sequences displayed similar patterns that were not seen in vif sequences from epidemiologically unlinked individuals. The functional domains, including the two cysteines at positions 114 and 133, a serine phosphorylation site at position 144, and the C-terminal ba...Continue Reading

References

Jan 1, 1992·Virus Genes·M S Oberste, M A Gonda
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T McNearneyL Ratner
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K CichutekR Kurth
Jul 1, 1991·AIDS Research and Human Retroviruses·J D OramJ C Booth
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T McNearneyL Ratner
Nov 25, 1988·Science·B D PrestonL A Loeb
Feb 1, 1989·Molecular and Cellular Biology·J D RobertsT A Kunkel
Nov 18, 1989·BMJ : British Medical Journal·S K HiraP L Perine
Jun 22, 1989·The New England Journal of Medicine·R W RyderK Mwandagalirwa
Aug 2, 1986·Lancet·S SprecherM Degueldre
Aug 15, 1987·Lancet·P LepageS Sprecher
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Sep 1, 1987·Journal of Medical Virology·J AlbertB Christensson
Nov 16, 1995·Nature·B T KorberS Wolinsky
Aug 15, 1994·Virology·U WielandJ E Kühn

❮ Previous
Next ❯

Citations

Jun 29, 2001·AIDS Research and Human Retroviruses·M HusainN Ahmad
Aug 4, 2001·AIDS Research and Human Retroviruses·V R YedavalliN Ahmad
Dec 29, 2005·AIDS Research and Human Retroviruses·Rajesh RamakrishnanNafees Ahmad
Mar 11, 2008·AIDS Research and Human Retroviruses·Roshni MehtaNafees Ahmad
Jan 13, 2010·AIDS Research and Human Retroviruses·Stephen K W TsuiShui-Shan Lee
May 2, 2017·The Open Virology Journal·Nafees AhmadShahid N Ahmad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.