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Conservation of an RNA regulatory map between Drosophila and mammals

Genome Research

Oct 6, 2010

Angela N BrooksBrenton R Graveley

Abstract

Alternative splicing is generally controlled by proteins that bind directly to regulatory sequence elements and either activate or repress splicing of adjacent splice sites in a target pre-mRNA. Here, we have combined RNAi and mRNA-seq to identify exons that are regulated by Pasilla (PS...read more

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
NOVA1 protein, human
Nested Transcripts
Conserved Sequence
NOVA2 wt Allele
Exons
Primary RNA Transcript
Cosuppression
Drosophila melanogaster Proteins
Candidate Disease Gene
5
1
304
Paper Details
References
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  • Citations79
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  • References39
  • Citations79
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Conservation of an RNA regulatory map between Drosophila and mammals

Genome Research

Oct 6, 2010

Angela N BrooksBrenton R Graveley

PMID: 20921232

DOI: 10.1101/gr.108662.110

Abstract

Alternative splicing is generally controlled by proteins that bind directly to regulatory sequence elements and either activate or repress splicing of adjacent splice sites in a target pre-mRNA. Here, we have combined RNAi and mRNA-seq to identify exons that are regulated by Pasilla (PS...read more

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
NOVA1 protein, human
Nested Transcripts
Conserved Sequence
NOVA2 wt Allele
Exons
Primary RNA Transcript
Cosuppression
Drosophila melanogaster Proteins
Candidate Disease Gene
5
1
304

Feeds With Similar Papers

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

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The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Discover the latest research on RNA splicing and co-transcriptional splicing in this feed.

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Paper Details
References
  • References39
  • Citations79
1234
  • References39
  • Citations79
12345...

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