Mar 1, 1991

Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates

G HannigM Schartl


The src-gene family in mammals and birds consists of 9 closely related protein tyrosine kinases. We have cloned the c-yes and fyn homologues of the src-family from the teleost fish Xiphophorus helleri. Both genes show a high degree of sequence conservation and exhibit all structural motifs diagnostic for functional src-like protein tyrosine kinases. Sequence comparisons revealed three domains (exon 2, exons 3-6, exons 7-12) which evolve at different rates. Both genes exhibit an identical expression pattern, with preferential expression in neural tissues. No transcripts of c-yes were found in liver which is contrary to the situation in higher vertebrates. In malignant melanoma, elevated levels of c-yes and fyn were detected indicating a possible function during secondary steps of tumor progression for src-related tyrosine kinases.

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Mentioned in this Paper

Src-Family Kinases
FYN protein, human
Proto-Oncogene Proteins c-yes
Homologous Sequences, Nucleic Acid
Proto-Oncogene Protein p72(fyn)
Northern Blot
Protein Tyrosine Kinase
Biological Evolution

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