PMID: 9529259Apr 7, 1998Paper

Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases

Cell
C ChengS Shuman

Abstract

Vaccinia DNA topoisomerase breaks and rejoins DNA strands through a DNA-(3'-phosphotyrosyl)-enzyme intermediate. A C-terminal catalytic domain, Topo(81-314), suffices for transesterification chemistry. The domain contains a constellation of five amino acids, conserved in all eukaryotic type IB topoisomerases, that catalyzes attack of the tyrosine nucleophile on the scissile phosphate. The structure of the catalytic domain, consisting of ten alpha helices and a three-strand beta sheet, resembles the catalytic domains of site-specific recombinases that act via a topoisomerase IB-like mechanism. The topoisomerase catalytic pentad is conserved in the tertiary structures of the recombinases despite scant sequence similarity overall. This implies that the catalytic domains of type IB topoisomerases and recombinases derive from a common ancestral strand transferase.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Y Kikuchi, H A Nash
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Shuman
Mar 25, 1991·Nucleic Acids Research·S KroghB J Bonven
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S Shuman
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R M LynnJ C Wang
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S ShumanS G Morham
May 12, 1995·The Journal of Biological Chemistry·J Sekiguchi, S Shuman
May 17, 1995·Biochimica Et Biophysica Acta·M GuptaY Pommier
Sep 5, 1993·Journal of Molecular Biology·L Holm, C Sander
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J SekiguchiS Shuman
Mar 1, 1996·European Journal of Biochemistry·A D Jensen, J Q Svejstrup
Jan 1, 1996·Annual Review of Biochemistry·J C Wang
Jan 1, 1994·Advances in Pharmacology·P R Caron, J C Wang
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·R S TirumalaiA Landy
Oct 6, 1997·The EMBO Journal·H S SubramanyaD B Wigley
Nov 14, 1997·The EMBO Journal·S ShumanJ Sekiguchi
Nov 14, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L Rothenberg
Mar 7, 1998·Structure·W Yang, K Mizuuchi

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Citations

Dec 4, 2002·Journal of Molecular Biology·Michael TekleSimone E Nunes-Düby
Dec 4, 2002·Journal of Molecular Biology·Dibyendu SarkarArthur Landy
Feb 1, 2003·Journal of Molecular Biology·Adam B ConwayPhoebe A Rice
Feb 1, 2003·Journal of Molecular Biology·Linda Lee, Paul D Sadowski
May 28, 2003·Journal of Molecular Biology·Srisunder SubramaniamMark P Foster
Jun 26, 2003·Journal of Molecular Biology·Félicie F AndersenBirgitta R Knudsen
Jul 17, 1999·Trends in Neurosciences·E CattaneoC De-Fraja
Sep 28, 1998·Biochimica Et Biophysica Acta·J M Berger
Sep 28, 1998·Biochimica Et Biophysica Acta·Y PommierD Strumberg
Sep 28, 1998·Biochimica Et Biophysica Acta·S Shuman
Nov 27, 1999·Structure·A Mondragón, R DiGate
Dec 17, 2002·Critical Reviews in Oncology/hematology·Christian Bailly
Aug 30, 2008·Quarterly Reviews of Biophysics·Allyn J Schoeffler, James M Berger
Sep 22, 2010·Quarterly Reviews of Biophysics·Wei Yang
Jan 13, 2006·Nature Chemical Biology·Kaushik GhoshGregory D Van Duyne
Nov 24, 2011·Nature Reviews. Molecular Cell Biology·Seychelle M VosJames M Berger
Sep 22, 1999·Pathology Oncology Research : POR·A K Larsen, C Gobert
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Berit Olsen Krogh, Stewart Shuman
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jonathan M WojciakRobert T Clubb
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Bhupesh TanejaAlfonso Mondragón
Jan 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gregory D Van Duyne
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·G I BelovaA I Slesarev
Jun 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Annette L BodleyTheresa A Shapiro
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y PommierD M Jerina
Oct 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael H WooMary-Ann Bjornsti
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Landy
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·F GuoG D Van Duyne
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·C GobertA K Larsen
Jan 5, 2012·The Journal of Biological Chemistry·Thibaud Perriches, Martin R Singleton
Jan 1, 2000·Journal of Biomolecular Structure & Dynamics·G B KoudelkaM Ciubotaru
Oct 3, 2009·Journal of Biomolecular Structure & Dynamics·D'Annessa IldaDesideri Alessandro
Feb 2, 1999·The EMBO Journal·J LeeI Grainge
Jun 28, 2000·Nucleic Acids Research·N V Grishin

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