PMID: 9535657May 2, 1998Paper

Conservation of substrate recognition mechanisms by tRNA splicing endonucleases

Science
S FabbriG P Tocchini-Valentini

Abstract

Accuracy in transfer RNA (tRNA) splicing is essential for the formation of functional tRNAs, and hence for gene expression, in both Eukaryotes and Archaea. The specificity for recognition of the tRNA precursor (pre-tRNA) resides in the endonuclease, which removes the intron by making two independent endonucleolytic cleavages. Although the eukaryal and archaeal enzymes appear to use different features of pre-tRNAs to determine the sites of cleavage, analysis of hybrid pre-tRNA substrates containing eukaryal and archaeal sequences, described here, reveals that the eukaryal enzyme retains the ability to use the archaeal recognition signals. This result indicates that there may be a common ancestral mechanism for recognition of pre-tRNA by proteins.

Citations

Mar 20, 2012·Cellular and Molecular Life Sciences : CMLS·Johannes PopowJavier Martinez
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gianfranco Di SegniGlauco P Tocchini-Valentini
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-ValentiniGlauco P Tocchini-Valentini
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-ValentiniGlauco P Tocchini-Valentini
Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-Valentini, Glauco P Tocchini-Valentini
Mar 27, 2001·EMBO Reports·P FruscoloniG P Tocchini-Valentini
Dec 19, 1998·The EMBO Journal·G J ArtsI W Mattaj
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Dec 3, 2004·RNA·Gianfranco Di SegniGlauco P Tocchini-Valentini
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-ValentiniGlauco P Tocchini-Valentini
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-ValentiniGlauco P Tocchini-Valentini
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·S L SpinelliE M Phizicky
Oct 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe D Tocchini-ValentiniGlauco P Tocchini-Valentini
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