Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog

Genes & Development
L V GoodrichM P Scott

Abstract

The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 26, 1992·Cell·R Nusse, H E Varmus
Sep 12, 1991·Nature·P W InghamY Nakano
Jan 1, 1981·Annual Review of Biochemistry·S C Hubbard, R J Ivatt
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Jan 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M H Saier
Dec 2, 1994·Science·J J LeeP A Beachy
Jul 1, 1994·Developmental Biology·K SchuskeM P Scott
Jul 1, 1993·Mechanisms of Development·A M TaylorP W Ingham
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·O PourquiéN M Le Douarin

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Citations

Mar 30, 1999·The Journal of Comparative Neurology·J M HallT E Finger
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·S L Pomeroy, J Y Kim
Jul 14, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K M Bhat
May 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Vervoort
Mar 29, 2001·The Journal of Pathology·G Saldanha
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A N GarrattC Birchmeier
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E DahlR Balling
Sep 1, 2005·Journal of Genetics·Santhosh Girirajan, Sarah H Elsea
Nov 6, 2012·Pediatric Surgery International·Naho FujiwaraJennifer Thompson
Nov 1, 2011·Histochemistry and Cell Biology·Jong-Min LeeHan-Sung Jung
Oct 2, 2009·Oral and Maxillofacial Surgery·José A García de MarcosEnrique Poblet
Mar 17, 2004·Molecular and Cellular Neurosciences·J CoulombeM Ruat
Mar 22, 2003·Developmental Biology·Joshua M H HallThomas E Finger
Aug 19, 2003·Developmental Biology·Katja KoebernickTomas Pieler
Nov 5, 2003·Developmental Biology·Tammy EllisBrandon J Wainwright
Nov 19, 2003·Developmental Biology·Kinga MichnoPaul A Hamel
Sep 11, 2002·Brain Research. Developmental Brain Research·Kanae OhsakiShun Nakamura
Jan 30, 2002·Trends in Neurosciences·Elisa Martí, Paola Bovolenta
Apr 5, 2002·Trends in Genetics : TIG·Patricia E Kuwabara, Michel Labouesse
Jan 1, 1997·Trends in Genetics : TIG·M HammerschmidtA P McMahon
Sep 28, 1999·Trends in Genetics : TIG·A Ruiz i Altaba
Mar 12, 2004·Cancer Letters·Ariel Ruiz i AltabaPilar Sánchez
Oct 1, 1996·Dermatologic Clinics·K S StennS M Prouty
Jan 5, 2002·Journal of Physiology, Paris·Dorota CharytoniukElisabeth Traiffort
Dec 1, 1996·Current Opinion in Cell Biology·I Thesleff, P Nieminen
Sep 8, 1998·Current Opinion in Genetics & Development·A Di Gregorio, M Levine
Sep 8, 1998·Current Opinion in Genetics & Development·B L Hogan, J M Yingling
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Pontén
Feb 1, 2003·Trends in Cell Biology·Pao-Tien Chuang, Andrew P McMahon
Dec 9, 2000·Biochimica Et Biophysica Acta·R K Mann, P A Beachy
Nov 15, 2012·Nature Communications·Maria Jimenez-SanchezDavid C Rubinsztein

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