Conservation of the modular structure of complement factor I through vertebrate evolution

Developmental and Comparative Immunology
T TeradoHiroshi Kimura

Abstract

Mammalian complement factor I plays pivotal roles in the regulation of complement activation and generation of important biological activities from C3. The evolutionary origin of factor I has been unclear except with regard to the molecular cloning of factor I from amphibian Xenopus. Here, we report the identification and characterization of factor I cDNA from the liver of the banded houndshark. The deduced amino acid sequence of shark factor I showed a modular organization that was completely identical to that of mammalian factor I, suggesting the functional conservation of factor I throughout vertebrate evolution. Functionally important amino acid residues such as the basic residues at the processing site and the residues at the active site of the serine protease domain are conserved. Repeated sequences composed of 16 amino acids were inserted at a site between the leader peptide and the factor I/membrane attacking complex module in the shark factor I. This repeat is missing from mammalian and amphibian factor I, and the biological significance of the sequence, if any, is not clear at the moment. There was only one copy of the shark factor I gene, and Northern blotting analysis showed that the shark factor I gene was expresse...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Apr 1, 1992·Neuron·K W TsimU J McMahan
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P J HanleyR L Raison
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jan 1, 1985·Annual Review of Biochemistry·R Kornfeld, S Kornfeld
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Feb 25, 1984·Journal of Molecular Biology·G von Heijne
Jan 22, 1982·Nucleic Acids Research·S M Mount
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·N L DalyR Smith
Oct 23, 1997·The Biochemical Journal·C G Ullman, S J Perkins
Jan 23, 1999·Immunological Reviews·S L Smith
Jul 30, 1999·Developmental and Comparative Immunology·M Nonaka, K Azumi
Sep 24, 1999·Developmental Biology·M OhashiS Fujiwara
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S MiyazawaM Nonaka
Mar 22, 2001·The Journal of Biological Chemistry·A KenjoT Fujita
May 18, 2001·Developmental and Comparative Immunology·S FranchiniJ D Lambris

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Citations

Aug 10, 2006·Immunogenetics·Masaru Nonaka, Ayuko Kimura
Jun 24, 2003·Developmental and Comparative Immunology·Miki NakaoTomoki Yano
Jun 23, 2009·Fish & Shellfish Immunology·Jason W AbernathyZhanjiang Liu
Oct 26, 2005·Journal of Thrombosis and Haemostasis : JTH·M J PageE Di Cera
Mar 19, 2016·Developmental and Comparative Immunology·Masayuki GoshimaMasaru Nonaka
Oct 24, 2006·Biochimica Et Biophysica Acta·Stefanos A TsiftsoglouRobert B Sim
Jul 8, 2015·Developmental and Comparative Immunology·Jinsong XiangZhenxia Sha
Jun 5, 2007·Immunobiology·Alister W Dodds, Misao Matsushita

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