PMID: 8948452Jun 15, 1995Paper

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1)

The Biochemical Journal
L Ala-KokkoE Vuorio

Abstract

Over 11,000 bp of previously undefined sequences of the human COL2A1 gene were defined. The results made it possible to compare the intron structures of a highly complex gene from man and mouse. Surprisingly, the sizes of the 53 introns of the two genes were highly conserved with a mean difference of 13%. After alignment of the sequences, 69% of the intron sequences were identical. The introns contained consensus sequences for the binding of over 100 different transcription factors that were conserved in the introns of the two genes. The first intron of the gene contained 80 conserved consensus sequences and the remaining 52 introns of the gene contained 106 conserved sequences for the binding of transcription factors. The 5'-end of intron 2 in both genes had a potential for forming a stem loop in RNA transcripts.

Citations

Mar 29, 2014·Connective Tissue Research·Audrey McAlinden
Oct 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M MetsärantaE Vuorio
Sep 17, 2004·American Journal of Medical Genetics. Part a·Mirka Marjanna VuoristoLeena Ala-Kokko
Sep 13, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Leah Rae DonahueMuriel T Davisson
Apr 1, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Audrey McAlindenLinda J Sandell
Jun 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T D GrantW A Horton
Jan 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P U RaniJ S Khillan
Aug 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laure ManeixPhilippe Galéra
Apr 4, 2003·European Journal of Human Genetics : EJHG·Miia MelkoniemiLeena Ala-Kokko
Mar 15, 2003·The Journal of Biological Chemistry·Lujian TanMary B Goldring
Jun 21, 2007·The Journal of Biological Chemistry·Audrey McAlindenLinda J Sandell
Sep 22, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M VälkkiläL Ala-Kokko
Nov 21, 2007·Matrix Biology : Journal of the International Society for Matrix Biology·Audrey McAlindenThomas M Hering

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