PMID: 2504435Aug 1, 1989Paper

Conservative treatment of diffuse carcinoma in situ of the bladder with repeated courses of intravesical therapy

British Journal of Urology
E Mukamel, J B deKernion

Abstract

We present a series of 13 patients with diffuse carcinoma in situ (CIS) of the bladder who failed an initial induction course of intravesical therapy with Mitomycin C, thiotepa, doxorubicin or Bacillus Calmette Guérin (BCG). Cystectomy, although indicated, was, for various reasons, not performed after the first failure of intravesical therapy and all patients were subsequently treated topically with the same or different agents. Of the 7 patients treated with 2 induction courses, 6 showed a complete response during a follow-up period of 24 to 42 months. Although 1 patient initially responded completely, he developed invasive transitional cell carcinoma (TCC) Grade IV 30 months later. Among the 3 patients who underwent 3 induction courses, 2 had a complete response at 42 and 60 months of follow-up and 1 developed TCC Grade IV with muscle invasion 18 months later. Two of the 3 patients treated with 4 induction courses are free of disease at 48 and 57 months; the third developed low grade, low stage TCC. This experience suggests that the majority of patients with CIS who fail initial treatment usually respond to further treatment with the same or a different drug. The question as to whether a second course of intravesical therapy,...Continue Reading

References

Nov 1, 1976·The Journal of Urology·A F AlthausenJ J Daly
Jan 1, 1975·British Journal of Urology·P R RiddleR C Pugh
Apr 1, 1980·Cancer·Mark S Soloway

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Citations

Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·M S Soloway, P E Perito
Aug 6, 2003·Critical Reviews in Oncology/hematology·Per-Uno Malmström
Mar 4, 2006·The Journal of Small Animal Practice·J J Pink

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