Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts

Genetics
Jennifer A YoungGerald R Smith

Abstract

During meiosis DNA double-strand breaks initiate recombination in the distantly related budding and fission yeasts and perhaps in most eukaryotes. Repair of broken meiotic DNA is essential for formation of viable gametes. We report here distinct but overlapping sets of proteins in these yeasts required for formation and repair of double-strand breaks. Meiotic DNA breakage in Schizosaccharomyces pombe did not require Rad50 or Rad32, although the homologs Rad50 and Mre11 are required in Saccharomyces cerevisiae; these proteins are required for meiotic DNA break repair in both yeasts. DNA breakage required the S. pombe midmeiosis transcription factor Mei4, but the structurally unrelated midmeiosis transcription factor Ndt80 is not required for breakage in S. cerevisiae. Rhp51, Swi5, and Rad22 + Rti1 were required for full levels of DNA repair in S. pombe, as are the related S. cerevisiae proteins Rad51, Sae3, and Rad52. Dmc1 was not required for repair in S. pombe, but its homolog Dmc1 is required in the well-studied strain SK1 of S. cerevisiae. Additional proteins required in one yeast have no obvious homologs in the other yeast. The occurrence of conserved and nonconserved proteins indicates potential diversity in the mechanism ...Continue Reading

References

Sep 1, 1989·Genetics·A S Ponticelli, G R Smith
Feb 7, 1967·Biochimica Et Biophysica Acta·J E Cummins, J M Mitchison
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R EgelA J Klar
Nov 1, 1995·Genes & Development·B RockmillG S Roeder
Sep 25, 1993·Nucleic Acids Research·D F MurisA Pastink
Feb 1, 1993·Current Genetics·U StyrkársdóttirO Nielsen
Oct 25, 1996·Science·A GoffeauS G Oliver
Jan 31, 1997·Science·R B Nicklas
Oct 23, 1997·Genes & Development·G S Roeder
Apr 16, 1998·The Journal of Biological Chemistry·E P RogakouW M Bonner
Jul 22, 1998·Molecular & General Genetics : MGG·R Ding, G R Smith
Sep 30, 1998·Progress in Nucleic Acid Research and Molecular Biology·M E Fox, G R Smith
Oct 23, 1998·Science·S ChuI Herskowitz
Dec 9, 1998·Cell·J E Haber
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·F Pâques, J E Haber
Mar 16, 2000·The EMBO Journal·B Arcangioli, R de Lahondès
Jul 6, 2000·Molecular Cell·M D CervantesG R Smith
Jul 25, 2000·Nucleic Acids Research·K FukushimaH Nojima
Aug 1, 2000·Mutation Research·P SungS Van Komen
Aug 23, 2000·Current Genetics·D Zenvirth, G Simchen
Dec 6, 2000·Mutation Research· van den Bosch MA Pastink
Mar 10, 2001·Nature Genetics·S K MahadevaiahP S Burgoyne
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·L Davis, G R Smith

❮ Previous
Next ❯

Citations

Aug 4, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Valérie Borde
Mar 10, 2009·The Journal of Biological Chemistry·Susan R FerrariDouglas K Bishop
Aug 3, 2012·Nucleic Acids Research·Sophie Wehrkamp-RichterMichael N Boddy
Oct 4, 2013·Nucleic Acids Research·Randy W HyppaGerald R Smith
Oct 1, 2013·Nucleic Acids Research·Guan-Chin SuPeter Chi
Jul 4, 2008·Annual Review of Cell and Developmental Biology·Needhi Bhalla, Abby F Dernburg
Aug 29, 2007·PLoS Genetics·Gareth A CromieGerald R Smith
Oct 7, 2004·Genetics·Chad EllermeierGerald R Smith
Jun 20, 2008·Genetics·Gareth A CromieGerald R Smith
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joseph A FarahGerald R Smith
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yuko Murakami-TonamiHiroshi Murakami
Jul 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chad Ellermeier, Gerald R Smith
Sep 14, 2011·Annual Review of Genetics·Lorraine S Symington, Jean Gautier
Jan 12, 2011·Journal of Experimental Botany·Bernd Edlinger, Peter Schlögelhofer
Feb 7, 2016·Seminars in Cell & Developmental Biology·Mridula Nambiar, Gerald R Smith
Feb 3, 2005·Yeast
Apr 21, 2009·Trends in Biochemical Sciences·Eleni P Mimitou, Lorraine S Symington
Aug 25, 2007·DNA Repair·Nami HarutaHiroshi Iwasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.