PMID: 9175602May 2, 1997Paper

Conserved elements in the 5' regulatory region of the amyloid precursor protein gene in primates

Neuroscience Letters
R AdroerR Oliva

Abstract

Oligonucleotides corresponding to conserved sites between the human and mouse amyloid precursor protein (APP) genes have been used to polymerase chain reaction (PCR) amplify and sequence the promoter region of the APP gene from chimpanzee, gorilla, orang-utan, papio and African green monkey. Several novel conserved potentially-regulatory sequences of the APP gene have been detected after alignment of the APP promoter sequences: an apolipoprotein E-B1 (APOE-B1) element at position -450, also present in the APOE gene, two activator protein-2 (AP-2) sites at positions -450 and -301 and an intermediate early-1 gene (IE1) site at position -280. These elements are conserved in all mammalian APP promoter sequences studied. Additionally a previously detected heat shock element (HSE) at position -317, and an activator protein-1 (AP-1) site at position -350 are also conserved. Knowledge of the essential regulatory elements at the APP gene constitute the basis for understanding its transcriptional control and subsequent model studies.

References

Jul 25, 1991·Nucleic Acids Research·R H DonJ S Mattick
Jan 1, 1991·International Psychogeriatrics·M W DyskenW H Frey
Feb 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J MartinD L Price
May 31, 1990·Biochemical and Biophysical Research Communications·A MiliciK Beyereuther
Apr 1, 1991·Computer Applications in the Biosciences : CABIOS·D S Prestridge
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GhazalL Hennighausen
Jun 1, 1988·Molecular and Cellular Biology·J H Park, M W Taylor
Apr 21, 1995·Neuroscience Letters·R AdroerR Oliva
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Jun 25, 2005·Current Alzheimer Research·Beka Solomon

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