Conserved lipoprotein H.8 of pathogenic Neisseria consists entirely of pentapeptide repeats

Molecular Microbiology
J P WoodsJ G Cannon

Abstract

The pathogenic Neisseria, N. gonorrhoeae and N. meningitidis, possess an outer membrane protein (OMP), designated H.8, with a conserved monoclonal antibody (MAb)-binding epitope. We determined the DNA sequence of a gonococcal H.8 gene, and confirmed the relationship between the cloned gene and the H.8 OMP by constructing a gonococcal mutant lacking H.8. The predicted H.8 OMP is a lipoprotein 71 amino acids in length, composed of 13 repeats of a consensus sequence AAEAP with perfect 5-residue periodicity. The AAEAP units form a repeating epitope that comprises the entire predicted sequence of the protein.

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Citations

Jan 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·W D Zollinger, E Moran
Jan 10, 2003·Molecular Microbiology·Lori A S SnyderNigel J Saunders
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